Entry Detail

General Information

Database ID: LDA0001062
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GHET1
Full Name:gastric carcinoma proliferation enhancing transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:lncRNA-GHET1
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):148987527End Site(bp):148989429
External Links:
Ensembl ID:ENSG00000281189
Ensembl Transcript ID:N/A
Entrez Gene:102723099.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Carcinoma, Renal Cell  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Head and Neck Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//Tunel//CCK8//qRT-PCR//RIP//IF//Flow Cytometry//MTT//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30948501
Disease Name:Uterine Cervical Neoplasms
Sample:cervical cancer tissues,cell lines
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:In our study, we found GHET1 expression was markedly elevated in cervical cancer tissue specimens and cell lines compared with adjacent normal cervical tissue specimens and human normal cervical cell line, respectively.
Causality:Yes
Causal Description:Knockdown of GHET1 expression markedly inhibits cervical cancer cell proliferation, migration, and invasion. The loss-of-function study indicated knockdown of GHET1 expression markedly inhibits cervical cancer cell proliferation, migration, and invasion.
Clinical-realted Application:Then, we found high expression of GHET1 is a useful biomarker to discriminate cervical cancer tissues from non-tumorous tissues, and associated with advanced clinical stage, lymph node metastasis, distant metastasis and poor histological grade in cervical cancer patients.

[2] PubMed ID:31682716
Disease Name:Uterine Cervical Neoplasms
Sample:cell lines
Dysfunction Pattern:regulation[AKT/mTOR and Wnt/β-catenin signaling pathways]
Validated Method:Western Blot//CCK8//qRT-PCR//RIP//Transwell Assay//IF
Description:We proposed to examine the biological role of GHET1 in CC and the underlying mechanism and validated the up-regulated expression of GHET1 in CC cell lines. In conclusion, we revealed that down-regulation of GHET1 suppresses cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways, indicating GHET1 as a promising molecular biomarker for CC treatment improvement.
Causality:Yes
Causal Description:Loss-of-function assays demonstrated that down-regulation of GHET1 inhibited cell growth, migration and epithelial-to-mesenchymal transition (EMT) in CC.
Clinical-realted Application:

[3] PubMed ID:32176622
Disease Name:Uterine Cervical Neoplasms
Sample:cancer tissues
Dysfunction Pattern:regulation[PTEN/PI3 K/AKT signalling pathway]
Validated Method:Western Blot//Wound Healing Assay//Tunel//Flow Cytometry//qRT-PCR//MTT//IHC//Transwell Assay
Description:The expression levels of lncRNA GHET1 and PTEN protein differed significantly between cancer and adjacent normal tissues (P< 0.05) and were negatively correlated in the clinical data. GHET1 knockdown suppressed cervical carcinoma development via the PTEN/PI3 K/AKT signalling pathway.
Causality:Yes
Causal Description: In vitro, proliferation rateswere significantly down-regulated in SiHa and HeLa cells. The GHET1 knockdown (si-GHET1) groups showed significantly higher G1 phase and apoptosis rates and significantly suppressed invasion and migration abilities compared with the normal control (NC) group (P< 0.05 for all).
Clinical-realted Application: