Entry Detail

General Information

Database ID: LDA0001063
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GHET1
Full Name:gastric carcinoma proliferation enhancing transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:lncRNA-GHET1
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):148987527End Site(bp):148989429
External Links:
Ensembl ID:ENSG00000281189
Ensembl Transcript ID:N/A
Entrez Gene:102723099.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Carcinoma, Renal Cell  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Head and Neck Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013964
Disease Name:Thyroid Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the THYROID GLAND.
Alias:Thyroid Neoplasms//Neoplasm, Thyroid//Thyroid Neoplasm//Neoplasms, Thyroid//Thyroid Carcinoma//Carcinoma, Thyroid//Carcinomas, Thyroid//Thyroid Carcinomas//Cancer of Thyroid//Thyroid Cancers//Thyroid Cancer//Cancer, Thyroid//Cancers, Thyroid//Cancer of the Thyroid//Thyroid Adenoma//Adenoma, Thyroid//Adenomas, Thyroid//Thyroid Adenomas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:170
Network:
Top Causal ncRNAs:
hsa_circ_0067934  (Score: 0.999893)
TMC6  (Score: 0.999893)
TMC6  (Score: 0.999893)
hsa_circ_0067934  (Score: 0.999893)
HOTAIRM1  (Score: 0.985791)
H19  (Score: 0.985791)
NORAD  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC2  (Score: 0.985791)
hsa_circ_0058124  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35116711
Disease Name:Thyroid Neoplasms
Sample: TC tissues
Dysfunction Pattern:Expression [highly expressed]
Validated Method:Wound Healing Assay//Flow Cytometry//qRT-PCR//CCK8//Transwell Assay
Description:Our results showed that LncRNA GHET1 was significantly more upregulated in TC tissues than in adjacent normal tissues. LncRNA GHET1 was also increased in thyroid cancer cell lines compared to normal thyroid cell lines. The upregulation of LncRNA GHET1 was significantly associated with tumor invasion, gender, and lymph node metastasis in patients with thyroid cancer. The in vitro studies showed that silencing LncRNA GHET1 in BCPAP cells inhibited cell proliferation, cell invasion, and migration. Silencing of LncRNA GHETI also promoted the cell apoptotic rate, caused an increase in the cell population at the G0/G1 phase, and decreased the cell population at the S phase. 
Causality:Yes
Causal Description:The in vitro studies showed that silencing LncRNA GHET1 in BCPAP cells inhibited cell proliferation, cell invasion, and migration. Silencing of LncRNA GHETI also promoted the cell apoptotic rate, caused an increase in the cell population at the G0/G1 phase, and decreased the cell population at the S phase. 
Clinical-realted Application:A recent study indicated that an increased LncRNA GHET1 expression level is associated with poor OS, tumor progression, and TNM stage in patients with multiple tumors and may serve as a useful prognostic biomarker in Chinese cancer patients