Entry Detail


General Information

Database ID: LDA0001065
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GHET1
Full Name:gastric carcinoma proliferation enhancing transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:lncRNA-GHET1
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):148987527End Site(bp):148989429
External Links:
Ensembl ID:ENSG00000281189
Ensembl Transcript ID:N/A
Entrez Gene:102723099.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Carcinoma, Renal Cell  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Head and Neck Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11934D006258
Disease Name:head and neck cancerHead and Neck Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx.Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Alias:head and neck neoplasm//head and neck tumours//head/neck neoplasm//tumor of head and neckHead and Neck Neoplasms//Neoplasms, Head and Neck//Head, Neck Neoplasms//Head and Neck Neoplasm//Cancer of Head and Neck//Head and Neck Cancer//Cancer of the Head and Neck//Upper Aerodigestive Tract Neoplasms//UADT Neoplasm//Neoplasm, UADT//Neoplasms, UADT//UADT Neoplasms//Neoplasms, Upper Aerodigestive Tract//Upper Aerodigestive Tract Neoplasm//Head Neoplasms//Neoplasms, Head//Head Neoplasm//Neoplasm, Head//Neck Neoplasms//Neoplasms, Neck//Neck Neoplasm//Neoplasm, Neck//Cancer of Head//Head Cancers//Head Cancer//Cancer, Head//Cancers, Head//Cancer of the Head//Cancer of Neck//Neck Cancers//Neck Cancer//Cancer, Neck//Cancers, Neck//Cancer of the Neck

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
GHET1  (Score: 0.731059)
GHET1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Flow Cytometry//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:29725422
Disease Name:Head and Neck Neoplasms
Sample:HNC tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:CCK8//qRT-PCR//Flow Cytometry//Transwell Assay
Description:The expression level of GHET1 was significantly increased in HNC tissues, compared with paired adjacent normal tissues.
Causality:Yes
Causal Description:Furthermore, inhibition of GHET1 suppressed cell proliferation, induced cell apoptosis and caused cell cycle arrest in vitro. In addition, GHET1 silencing inhibited cell migration and invasion.
Clinical-realted Application:High GHET1 expression was significantly associated with advanced Tumor-Node-Metastasis stages and poor prognosis.