Entry Detail

General Information

Database ID: LDA0001066
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GFRA1
Full Name:GDNF family receptor alpha 1
Category:LncRNA
Species:Homo sapiens
Synonyms:GDNFR|GDNFR-alpha-1|GDNFRA|GFR-ALPHA-1|GFRalpha-1|RET1L|RETL1|RHDA4|TRNR1
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):116056925End Site(bp):116274705
External Links:
Ensembl ID:ENSG00000151892
Ensembl Transcript ID:N/A
Entrez Gene:2674.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10283D011471
Disease Name:prostate cancerProstatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A male reproductive organ cancer that is located_in the prostate.Tumors or cancer of the PROSTATE.
Alias:NGP - new growth of prostate//hereditary prostate cancer//malignant tumor of the prostate//prostate cancer, familial//prostate neoplasm//prostatic cancer//prostatic neoplasm//tumor of the prostateProstatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

 

Disease Association Statistics

Total Associated ncRNA Number:566   
More Information
Causal ncRNA Number:414
Network:
Top Causal ncRNAs:
TUG1  (Score: 1)
SNHG1  (Score: 1)
MALAT1  (Score: 1)
NORAD  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
SNHG3  (Score: 1)
MALAT1  (Score: 1)
SNHG1  (Score: 1)
NORAD  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qPCR//RIP//PCR//IP//ELISA//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35832649
Disease Name:Prostatic Neoplasms
Sample:PCa tumor tissues
Dysfunction Pattern:Interaction(miR-3064-5p/HECTD1 axis)
Validated Method:RNA Pull-Down//Western Blot//qPCR//RIP//PCR//IP//ELISA//Bioinformatics Analysis//IF
Description:In this study, circRNA microarrays using four pairs of PCa tissues were utilized to show that circGFRA1 was upregulated in PCa tumor tissues, our results showed that LMX1B could bind to the GFRA1 promoter and regulate circGFRA1 expression in PCa cells and circGFRA1 upregulated HECTD1 expression through sponging miR-3064-5p.
Causality:Yes
Causal Description:CircGFRA1 is suggested to play an oncogene role in PCa progression as the silencing of circGFRA1 inhibited the proliferation, migration, and immune escape activity of PCa cells.
Clinical-realted Application: