Entry Detail

General Information

Database ID: LDA0001228
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LOXL1-AS1
Full Name:LOXL1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:15
Strand:-
Coordinate:
Start Site(bp):73917468End Site(bp):73928248
External Links:
Ensembl ID:ENSG00000261801
Ensembl Transcript ID:N/A
Entrez Gene:100287616.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:44   
More Information
Causal Disease Number:42
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3744
Disease Name:cervical squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
Alias:squamous cell carcinoma of cervix//squamous cell carcinoma of the Cervix Uteri

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:50
Network:
Top Causal ncRNAs:
MCM3AP-AS1  (Score: 0.985791)
MCM3AP-AS1  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
SLC16A1-AS1  (Score: 0.731059)
GATA6-AS  (Score: 0.731059)
BLACAT1  (Score: 0.731059)
CASC9-1  (Score: 0.731059)
DGUOK-AS1  (Score: 0.731059)
MACC1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32881598
Disease Name:cervical squamous cell carcinoma
Sample:CSCC tissues
Dysfunction Pattern:interaction[miR-21]
Validated Method:Transwell Assay//qRT-PCR//Luciferase Report Assay//Western Blot
Description:We observed that LOXL1-AS1 was downregulated in CSCC.Therefore, LOXL1-AS1 may promote CSCC cell invasion and migration by sponging miR-21 to upregulate RHOB.
Causality:Yes
Causal Description:Cell invasion and migration analysis showed decreased invasion and migration rates of CSCC cells after LOXL1-AS1 and RHOB overexpression.
Clinical-realted Application: