Entry Detail

General Information

Database ID: LDA0001247
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LOXL1-AS1
Full Name:LOXL1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:15
Strand:-
Coordinate:
Start Site(bp):73917468End Site(bp):73928248
External Links:
Ensembl ID:ENSG00000261801
Ensembl Transcript ID:N/A
Entrez Gene:100287616.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:44   
More Information
Causal Disease Number:42
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31908498
Disease Name:Stomach Neoplasms
Sample:GC tissues
Dysfunction Pattern:Regulation[miR-142-5p/PIK3CA Axis]
Validated Method:CCK8//qRT-PCR//Western Blot//Transwell Assay
Description:LOXL1-AS1 expression in GC samples was significantly increased, which was correlated with unfavorable pathological indexes.Additionally, overexpressed LOXL1-AS1 notably reduced the expression of miR-142-5p, but enhanced the expression level of PIK3CA.
Causality:Yes
Causal Description:Additionally, overexpressed LOXL1-AS1 notably reduced the expression of miR-142-5p, but enhanced the expression level of PIK3CA. In vivo experiments further validated that knockdown of LOXL1-AS1 inhibited the growth and metastasis of GC cells via regulating miR-142-5p and PIK3CA.
Clinical-realted Application:Highly expressed LOXL1-AS1 was closely linked to shorter overall survival time and post-progression survival time of the patients.

[2] PubMed ID:31468594
Disease Name:Stomach Neoplasms
Sample:gastric cancer tissues and cells
Dysfunction Pattern:Interaction[miR-708-5p/USF1 pathway]
Validated Method:RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Description:LOXL1-AS1 was highly expressed in tissues and cells of gastric cancer.Rescue experiments testified the stimulative role of LOXL1-AS1/miR-708-5p/USF1 pathway in gastric cancer progression.
Causality:Yes
Causal Description:Our findings demonstrated that LOXL1-AS1 accelerated the deterioration of gastric cancer by inducing cell proliferation, migration, EMT and stemness.
Clinical-realted Application: