Entry Detail

General Information

Database ID: LDA0001307
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LMCD1-AS1
Full Name:LMCD1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:3
Strand:-
Coordinate:
Start Site(bp):8221147End Site(bp):8501658
External Links:
Ensembl ID:ENSG00000227110
Ensembl Transcript ID:N/A
Entrez Gene:100288428.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35000595
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues and cells
Dysfunction Pattern:Interaction(LMCD1-AS1/miR-526b-3p/OSBPL5 axis)
Validated Method:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay
Description: This paper was the first to probe the molecular regulatory mechanism of OSBPL5 involving the LMCD1-AS1/miR-526b-3p axis in NSCLC and our results revealed that the LMCD1-AS1/miR-526b-3p/OSBPL5 axis facilitates NSCLC cell proliferation, migration, invasion and EMT, which may offer a novel therapeutic direction for NSCLC.
Causality:Yes
Causal Description:Moreover, from rescue assays, we observed that OSBPL5 overexpression offset LMCD1-AS1 knockdown-mediated inhibition in cell proliferation, migration, invasion and EMT in NSCLC.
Clinical-realted Application: