Entry Detail

General Information

Database ID: LDA0001350
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC-PINT
Full Name:long intergenic non-protein coding RNA, p53 induced transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:LincRNA-Pint|MKLN1-AS1|PINT|PINT87aa|TISPL
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):130877562End Site(bp):131109925
External Links:
Ensembl ID:ENSG00000231721
Ensembl Transcript ID:N/A
Entrez Gene:378805.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:28   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Glioblastoma  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1909D008545
Disease Name:melanomaMelanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Alias:Naevocarcinoma//malignant melanomaMelanoma//Melanomas//Malignant Melanoma//Malignant Melanomas//Melanoma, Malignant//Melanomas, Malignant

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MALAT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TINCR  (Score: 0.985791)
LINC-PINT  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:31452772
Disease Name:Melanoma
Sample:melanoma tissues
Dysfunction Pattern:Interaction[downregulating lncRNA BANCR]
Validated Method:CCK8//qRT-PCR
Description:LINC-PINT was downregulated, while BRAF-activated non-coding RNA (BANCR) was upregulated in melanoma tissues compared with normal adjacent tissues. LINC-PINT was downregulated, while BRAF-activated non-coding RNA (BANCR) was upregulated in melanoma tissues compared with normal adjacent tissues. Expression levels of LINC-PINT decreased, while expression levels of BANCR increased with increasing tumor thickness. The expression levels of LINC-PINT and BANCR were inversely associated in melanoma tissues but not in healthy adjacent tissue. LINC-PINT overexpression downregulated BANCR expression in melanoma cells, while BANCR overexpression did not significantly affect LINC-PINT expression.
Causality:Yes
Causal Description:LINC-PINT overexpression inhibited melanoma cell proliferation in vitro compared to controls.
Clinical-realted Application:

[2] PubMed ID:31921860
Disease Name:Melanoma
Sample:cell lines
Dysfunction Pattern:Interaction[Recruiting EZH2]
Validated Method:CCK8//qRT-PCR//Flow Cytometry//Microarray//Colony Formation Assay//ChIP
Description: LINC-PINT was significantly downregulated in melanoma tissues and cell lines. In conclusion, LINC-PINT inhibits the tumorigenicity of melanoma through recruiting EZH2 to the promoter of its target genes, leading to H3K27 trimethylation and epigenetic silencing of target genes.
Causality:Yes
Causal Description:The overexpression of LINC-PINT in tumor cells resulted in significant tumor growth reduction and migration inhibition in A375, Mum2B and CRMM1 cells. Results based on the in vivo xenograft model were further consistent with the in vitro findings that LINC-PINT impeded growth and metastasis of melanoma cells.
Clinical-realted Application: