LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0001371
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

LINC-ROR

Full Name:

long intergenic non-protein coding RNA, regulator of reprogramming

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

ROR|lincRNA-RoR|lincRNA-ST8SIA3

Chromosome:

Strand:

Coordinate:

Start Site(bp):

57054559

End Site(bp):

57072119

External Links:

Ensembl ID:	ENSG00000258609
Ensembl Transcript ID:	N/A
Entrez Gene:	100885779.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

36 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Stomach Neoplasms (Score: 0.999998)

Glioblastoma (Score: 0.999893)

Nasopharyngeal carcinoma (Score: 0.985791)

Carcinoma, Renal Cell (Score: 0.985791)

Ovarian Neoplasms (Score: 0.985791)

Osteosarcoma (Score: 0.985791)

Nasopharyngeal carcinoma (Score: 0.985791)

Osteosarcoma (Score: 0.985791)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:5041	D004938
Disease Name:	esophageal cancer	Esophageal Neoplasms
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A gastrointestinal system cancer that is located_in the esophagus.	Tumors or cancer of the ESOPHAGUS.
Alias:	Ca lower third oesophagus//Ca middle third oesophagus//esophagus cancer//malignant neoplasm of distal third of esophagus//malignant neoplasm of lower third of oesophagus//malignant neoplasm of middle third of oesophagus//malignant neoplasm of proximal third of esophagus//malignant neoplasm of upper third esophagus//malignant tumor of Distal Third of esophagus//malignant tumor of Proximal Third of esophagus//malignant tumor of abdominal esophagus//malignant tumor of the middle Third of the esophagus	Esophageal Neoplasms//Esophageal Neoplasm//Neoplasm, Esophageal//Esophagus Neoplasm//Esophagus Neoplasms//Neoplasm, Esophagus//Neoplasms, Esophagus//Neoplasms, Esophageal//Cancer of Esophagus//Cancer of the Esophagus//Esophagus Cancer//Cancer, Esophagus//Cancers, Esophagus//Esophagus Cancers//Esophageal Cancer//Cancer, Esophageal//Cancers, Esophageal//Esophageal Cancers

Disease Association Statistics

Total Associated ncRNA Number:

202 More Information

Causal ncRNA Number:

148

Network:

Top Causal ncRNAs:

UCA1 (Score: 0.999893)

ADAMTS9-AS2 (Score: 0.985791)

circPRKCI (Score: 0.731059)

hsa_circ_0006168 (Score: 0.731059)

hsa_circ_0008717 (Score: 0.731059)

hsa_circ_0023397 (Score: 0.731059)

LINC01234 (Score: 0.731059)

LINC00963 (Score: 0.731059)

More Information

Evidence Support

Strong Evidence:	Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Weak Evidence:

Reference

[1] PubMed ID:	33312362
Disease Name:	Esophageal Neoplasms
Sample:	EC tissues and cells
Dysfunction Pattern:	regulation[miR-145/LMNB2 signal axis]
Validated Method:	Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Description:	ROR and LMNB2 were up-regulated and miR-145 was down-regulated in EC tissues and cells. LMNB2 which is regulated by ROR and miR-145 was highly expressed in EC and promoted the proliferation and migration of EC in vitro and in vivo.
Causality:	Yes
Causal Description:	The proliferation and migration of EC cells were promoted by overexpression of of ROR or LMNB2.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail