Entry Detail

General Information

Database ID: LDA0001372
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC-ROR
Full Name:long intergenic non-protein coding RNA, regulator of reprogramming
Category:LncRNA
Species:Homo sapiens
Synonyms:ROR|lincRNA-RoR|lincRNA-ST8SIA3
Chromosome:18
Strand:-
Coordinate:
Start Site(bp):57054559End Site(bp):57072119
External Links:
Ensembl ID:ENSG00000258609
Ensembl Transcript ID:N/A
Entrez Gene:100885779.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999998)
Stomach Neoplasms  (Score: 0.999998)
Glioblastoma  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Nasopharyngeal carcinoma  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9261C538339
Disease Name:nasopharynx carcinomaNasopharyngeal carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

 

Disease Association Statistics

Total Associated ncRNA Number:260   
More Information
Causal ncRNA Number:244
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 1)
ZFAS1  (Score: 1)
DANCR  (Score: 0.999893)
XIST  (Score: 0.999893)
XIST  (Score: 0.999893)
DANCR  (Score: 0.999893)
circZNF609  (Score: 0.985791)
hsa_circ_0008450  (Score: 0.985791)
PVT1  (Score: 0.985791)
circZNF609  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//qPCR//Migration Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36183926
Disease Name:Nasopharyngeal carcinoma
Sample:serum exosomes
Dysfunction Pattern:Regulation( p-AKT/p-VEGFR2 pathway )
Validated Method:Western Blot//Transfection//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//EdU Staining//Transwell Assay
Description:This study demonstrates that linc-ROR is substantially expressed in serum exosomes from NPC and can be taken up by HUVECs. Thus, the p-AKT/p-VEGFR2 pathway is the mechanism by which linc-ROR affects the aforementioned biological activities. By stimulating angiogenesis, linc-ROR appears to play a significant role in the course of NPC and could account for a therapeutic target.
Causality:Yes
Causal Description: Using qRT-PCR, the CCK8 test, the transwell migration assay, the wound healing assay, and the tube formation assay, we demonstrated that linc-ROR increases proliferation, migration, and angiogenesis in vitro. Similar to prior research, our results have shown that linc-ROR can stimulate tumor angiogenesis in the zebrafish model.
Clinical-realted Application:

[2] PubMed ID:36107245
Disease Name:Nasopharyngeal carcinoma
Sample:NPC patients
Dysfunction Pattern:Expression(lower expressed)
Validated Method:qPCR
Description: The median of TEP lncRNA ROR was significantly lower in NPC patients than that in normal subjects (0.0209 vs 0.0610, p = 0.0019), while no significant difference was found in plasma lncRNA ROR.
Causality:No
Causal Description:
Clinical-realted Application: