Entry Detail

General Information

Database ID: LDA0001376
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC-ROR
Full Name:long intergenic non-protein coding RNA, regulator of reprogramming
Category:LncRNA
Species:Homo sapiens
Synonyms:ROR|lincRNA-RoR|lincRNA-ST8SIA3
Chromosome:18
Strand:-
Coordinate:
Start Site(bp):57054559End Site(bp):57072119
External Links:
Ensembl ID:ENSG00000258609
Ensembl Transcript ID:N/A
Entrez Gene:100885779.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999998)
Stomach Neoplasms  (Score: 0.999998)
Glioblastoma  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Nasopharyngeal carcinoma  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11476D010024
Disease Name:osteoporosisOsteoporosis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Alias:Osteoporosis//Osteoporoses//Osteoporosis, Post-Traumatic//Osteoporosis, Post Traumatic//Post-Traumatic Osteoporoses//Post-Traumatic Osteoporosis//Osteoporosis, Senile//Osteoporoses, Senile//Senile Osteoporoses//Osteoporosis, Involutional//Senile Osteoporosis//Osteoporosis, Age-Related//Osteoporosis, Age Related//Bone Loss, Age-Related//Age-Related Bone Loss//Age-Related Bone Losses//Bone Loss, Age Related//Bone Losses, Age-Related//Age-Related Osteoporosis//Age Related Osteoporosis//Age-Related Osteoporoses//Osteoporoses, Age-Related

 

Disease Association Statistics

Total Associated ncRNA Number:32   
More Information
Causal ncRNA Number:20
Network:
Top Causal ncRNAs:
KCNQ1OT1  (Score: 0.985791)
hsa_circ_0002060  (Score: 0.985791)
hsa_circ_0002060  (Score: 0.985791)
KCNQ1OT1  (Score: 0.985791)
Mir22hg  (Score: 0.731059)
TERC  (Score: 0.731059)
WT1-AS  (Score: 0.731059)
PTCSC3  (Score: 0.731059)
AWPPH  (Score: 0.731059)
CCAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34617877
Disease Name:Osteoporosis
Sample:OP patients
Dysfunction Pattern:Interaction(miR-145-5p axis )
Validated Method:Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Description:LncRNA ROR was downregulated, and miR-145-5p was overexpressed in OP patients. Luciferase reporting assay verified the target relationship between ROR and miR-145-5p. MiR-145-5p downregulation reversed ROR silence mediated effect on MC3T3-E1 cell proliferation and apoptosis. LncRNA ROR is downregulated and miR-145-5p is highly expressed in OP patient
Causality:Yes
Causal Description:ROR knockdown promoted the MC3T3-E1 cell apoptosis and inhibited cell proliferation.
Clinical-realted Application:The combined diagnosis of ROR and miR-145-5p showed good diagnostic value for OP.