Entry Detail

General Information

Database ID: LDA0001378
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:lnc-CHAF1B-3
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
renal fibrosis  (Score: 0.731059)
renal fibrosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050855
Disease Name:renal fibrosis
Category:Disease Ontology
Type:Urogenital Diseases
Define:A kidney disease that is characterized by progressive detrimental connective tissue deposition of the kidney parenchyma leading to deterioration of renal function.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
Gas5  (Score: 0.731059)
lnc-CHAF1B-3  (Score: 0.731059)
hsa_circ_30032  (Score: 0.731059)
circPTPN14  (Score: 0.731059)
circPlekha7  (Score: 0.731059)
PVT1  (Score: 0.731059)
Gas5  (Score: 0.731059)
lnc-CHAF1B-3  (Score: 0.731059)
hsa_circ_30032  (Score: 0.731059)
circPTPN14  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:36700051
Disease Name:renal fibrosis
Sample:human renal proximal tubular cells
Dysfunction Pattern:Expression(highly expressed)
Validated Method:Western Blot//Transfection//qRT-PCR//RNA-seq//Microarray
Description:Microarray assays showed that expression of the lncRNA lnc-CHAF1B-3 (also called claudin 14 antisense RNA 1) was significantly upregulated in human renal proximal tubular cells by both transforming growth factor-β1 (TGF-β1) and hypoxic stimulation, accompanied with increased expression of EMT-related genes.
Causality:Yes
Causal Description:Knockdown of lnc-CHAF1B-3 significantly suppressed TGF-β1-induced upregulated expression of collagen type I alpha 1, cadherin-2, plasminogen activator inhibitor-1, snail family transcriptional repressor I (SNAI1) and SNAI2.
Clinical-realted Application: