Entry Detail

General Information

Database ID: LDA0001424
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:lnc-PKD2-2-3
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Cholangiocarcinoma  (Score: 0.985791)
Cholangiocarcinoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4928D018281
Disease Name:intrahepatic cholangiocarcinomaCholangiocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree.A malignant tumor arising from the epithelium of the BILE DUCTS.
Alias:Intrahepatic bile duct carcinoma//peripheral CholangiocarcinomaCholangiocarcinoma//Cholangiocarcinomas//Cholangiocellular Carcinoma//Carcinoma, Cholangiocellular//Carcinomas, Cholangiocellular//Cholangiocellular Carcinomas//Extrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Extrahepatic//Cholangiocarcinomas, Extrahepatic//Extrahepatic Cholangiocarcinomas//Intrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Intrahepatic//Cholangiocarcinomas, Intrahepatic//Intrahepatic Cholangiocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:144
Network:
Top Causal ncRNAs:
NNT-AS1  (Score: 0.999893)
NNT-AS1  (Score: 0.999893)
SNHG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TTN-AS1  (Score: 0.985791)
SNHG1  (Score: 0.985791)
AGAP2-AS1  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35965521
Disease Name:Cholangiocarcinoma
Sample:CCA tissues, CCA cell lines
Dysfunction Pattern:Interaction(Lnc-PKD2-2-3/miR-328/GPAM )
Validated Method:In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay
Description: Lnc-PKD2-2-3 and GPAM were higher, whereas miR-328 was lower in CCA tissues versus adjacent tissues and also in CCA cell lines versus control cells; meanwhile, they were correlated with each other (all P <0.05). MiR-328 knockdown induced CCA cell proliferation and invasion and also attenuated the effect of lnc-PKD2-2-3-knockdown in these functions (all P <0.05). Subsequently, GPAM knockdown reduced CCA cell proliferation and invasion and also weakened the effect of miR-328-knockdown in these functions (all P <0.05). Additionally, lnc-PKD2-2-3 positively regulated GPAM while negatively regulating miR-328. MiR-328 negatively modified GPAM in CCA cells. Luciferase gene reporter assays verified that lnc-PKD2-2-3 directly bound miR-328 and miR-328 directly bound GPAM. Finally, the lnc-PKD2-2-3/miR-328/GPAM network also regulated the 5-FU chemosensitivity of CCA cells.
Causality:Yes
Causal Description: Lnc-PKD2-2-3 knockdown decreased CCA cell proliferation, invasion, and increased apoptosis (all P <0.05), but lnc-PKD2-2-3 overexpression exhibited the opposite and weaker effect. In vivo experiments further revealed that lnc-PKD2-2-3 overexpression promoted tumor volume and weight but repressed tumor apoptosis in xenograft mice; meanwhile, it increased GPAM expression but decreased miR-328 expression (all P <0.05). Conversely, lnc-PKD2-2-3 knockdown exhibited the opposite effects (all P <0.05).
Clinical-realted Application:

[2] PubMed ID:31059014
Disease Name:Cholangiocarcinoma
Sample:cholangiocarcinoma tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Western Blot//Microarray
Description: RT‑qPCR validation revealed that lnc‑PKD2‑2‑3 was Expression[up-expression]regulated in CCA and associated with a higher Eastern Cooperative Oncology GroExpression[up-expression] performance score, poor differentiation, advanced TNM stage, increased carcinoembryonic antigen and poor overall survival in CCA patients.
Causality:No
Causal Description:
Clinical-realted Application: