Entry Detail

General Information

Database ID: LDA0001449
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:lncKRT16P6
Full Name:keratin 16 pseudogene 6
Category:LncRNA
Species:Homo sapiens
Synonyms:lncKRT16P6
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):16817983End Site(bp):16822553
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:353194.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
tongue squamous cell carcinoma  (Score: 0.731059)
tongue squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050865
Disease Name:tongue squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A head and neck squamous cell carcinoma that is located_in the tongue.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:140   
More Information
Causal ncRNA Number:70
Network:
Top Causal ncRNAs:
hsa_circ_0001742  (Score: 1)
hsa_circ_0001742  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
CASC15  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
CASC15  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//qRT-PCT//Western Blot//CCK8//Flow Cytometry//FISH//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35904180
Disease Name:tongue squamous cell carcinoma
Sample:TSCC tissues and cell lines
Dysfunction Pattern:Interaction(miR‑3180/GATAD2A )
Validated Method:In Vivo Experiment//qRT-PCT//Western Blot//CCK8//Flow Cytometry//FISH//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay
Description:Through RNA screening, the present study identified a novel long noncoding RNA (lncRNA), keratin 16 pseudogene 6 (lncKRT16P6), which was upregulated in TSCC tissues and cell lines and associated with TSCC tumor stage and differentiation grade. lncKRT16P6 sponged microRNA (miR)‑3180 and upregulated GATA zinc finger domain containing 2A (GATAD2A) expression. miR‑3180 inhibition reversed the lncKRT16P6 depletion‑induced attenuation of TSCC malignancy and GATAD2A depletion reversed the miR‑3180 silencing‑induced enhancement of TSCC malignancy.
Causality:Yes
Causal Description: Inhibition of lncKRT16P6 expression reduced TSCC cell migration, invasion and proliferation.
Clinical-realted Application:Through RNA screening, the present study identified a novel long noncoding RNA (lncRNA), keratin 16 pseudogene 6 (lncKRT16P6), which was upregulated in TSCC tissues and cell lines and associated with TSCC tumor stage and differentiation grade.