| [1] PubMed ID: | 30657561 |
| Disease Name: | tongue squamous cell carcinoma |
| Sample: | tongue cancer tissues,blood |
| Dysfunction Pattern: | Interaction[downregulating MMP-9] |
| Validated Method: | Western Blot//CCK8//qRT-PCR//Invasion Assay//Transwell Assay |
| Description: | The expression level of MALAT1 was remarkably higher in tumor tissues than that in adjacent healthy tissues. Serum MALAT1 was significantly higher in tongue cancer patients than in healthy controls.MALAT1 knockdown also reduced the phosphorylation level of Akt as well as the expression level of MMP-9. It showed no significant effects on Akt expression, while PI3K activator treatment reduced the inhibitory effects of MALAT1 knockdown on the proliferation, migration and invasion of tongue cancer cells. |
| Causality: | Yes |
| Causal Description: | MALAT1 knockdown markedly inhibits the proliferation, migration and invasion of tongue cancer cells. |
| Clinical-realted Application: | |
| [2] PubMed ID: | 31360193 |
| Disease Name: | tongue squamous cell carcinoma |
| Sample: | OSCC tissue |
| Dysfunction Pattern: | Expression[highly expressed] |
| Validated Method: | CCK8//qRT-PCR |
| Description: | MALAT-1 levels were significantly higher in the OSCC tissue than in the normal tissues (p < 0.004); no significant differences in UCA1, BC200 or SRA RNA levels were observed. |
| Causality: | Yes |
| Causal Description: | Knockdown of MALAT-1 by siRNA significantly suppressed proliferation of SSC4 cells (p < 0.004) and enhanced their apoptosis (p < 0.001). |
| Clinical-realted Application: | |
| [3] PubMed ID: | 30863103 |
| Disease Name: | tongue squamous cell carcinoma |
| Sample: | TSCC tissues and cells |
| Dysfunction Pattern: | Regulation[miR-140-5p-PAK1 pathway] |
| Validated Method: | RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay |
| Description: | The expression of MALAT1 and p21 (RAC1)-activated kinase 1 (PAK1) was upregulated and microRNA-140-5p (miR-140-5p) expression was downregulated in TSCC tissues and cells. MALAT1 contributed to TSCC progression via miR-140-5p-PAK1 regulatory axis, highlighting a potential target for TSCC management. |
| Causality: | Yes |
| Causal Description: | Moreover, MALAT1 knockdown inhibited proliferation, migration, and invasion by upregulating miR-140-5p expression in TSCC cells. |
| Clinical-realted Application: | |
| [4] PubMed ID: | 32383096 |
| Disease Name: | tongue squamous cell carcinoma |
| Sample: | tongue tissues |
| Dysfunction Pattern: | Expression[highly expressed] |
| Validated Method: | qRT-PCR |
| Description: | The expression of MALAT1 was upregulated in tongue SCC, compared to normal tongue tissues. |
| Causality: | No |
| Causal Description: | |
| Clinical-realted Application: | The expression level of MALAT1 was correlated to differentiation and stage of tongue SCC, and high MALAT1 expression was associated with low disease-free survival and overall survival rates. Moreover, advanced tongue SCC patients with high MALAT1 level had lower disease-free survival and decreased overall survival rate than patients with low MALAT1 level. |
|