Entry Detail

General Information

Database ID: LDA0001483
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:90D055959
Disease Name:degenerative disc diseaseIntervertebral Disc Degeneration
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Alias:cervical disc degenerative disease//intervertebral disc degeneration//lumbar disc degeneration//vertebral disc diseaseIntervertebral Disc Degeneration//Degeneration, Intervertebral Disc//Disc Degeneration, Intervertebral//Intervertebral Disc Degenerations//Disc Degeneration//Degeneration, Disc//Disc Degenerations//Intervertebral Disk Degeneration//Degeneration, Intervertebral Disk//Disk Degeneration, Intervertebral//Intervertebral Disk Degenerations//Disk Degeneration//Degeneration, Disk//Disk Degenerations//Disk Degradation//Degradation, Disk//Disk Degradations//Degenerative Disc Disease//Degenerative Disc Diseases//Disc Disease, Degenerative//Disc Degradation//Degradation, Disc//Disc Degradations//Degenerative Intervertebral Discs//Degenerative Intervertebral Disc//Disc, Degenerative Intervertebral//Intervertebral Disc, Degenerative//Degenerative Intervertebral Disks//Degenerative Intervertebral Disk//Disk, Degenerative Intervertebral//Intervertebral Disk, Degenerative

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
PART1  (Score: 0.731059)
RMRP  (Score: 0.731059)
circGLCE  (Score: 0.731059)
NRAD1  (Score: 0.731059)
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32228440
Disease Name:Intervertebral Disc Degeneration
Sample:IDD tissues
Dysfunction Pattern:regulation[MALAT1-miR-503-MAPK pathway]
Validated Method:qRT-PCR
Description:We validated the decreased expression of MALAT1 in the IDD tissues, which was associated with decreased Collagen II and Aggrecan expression.Our data suggested that the MALAT1-miR-503-MAPK pathway plays a critical role in NPCs, which may be a potential strategy for alleviating IDD.
Causality:Yes
Causal Description:In vitro, overexpressed MALAT1 could attenuate the effect of IL-1β on NPC proliferation, apoptosis, and Aggrecan degradation. In vivo, MALAT1 overexpression attenuated the severity of disc degeneration in IDD model rats.
Clinical-realted Application: