Entry Detail


General Information

Database ID: LDA0001511
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10591D011225
Disease Name:pre-eclampsiaPre-Eclampsia
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Alias:gestational hypertension//hypertension induced by pregnancy//pre-eclamptic toxaemia//preeclampsia//preeclampsia/eclampsia//pregnancy associated hypertension//pregnancy toxemia//proteinuric hypertension of pregnancy//toxaemia of pregnancyPre-Eclampsia//Pre Eclampsia//Preeclampsia//Pregnancy Toxemias//Pregnancy Toxemia//Toxemia, Pregnancy//Edema-Proteinuria-Hypertension Gestosis//Edema Proteinuria Hypertension Gestosis//Gestosis, Edema-Proteinuria-Hypertension//Hypertension-Edema-Proteinuria Gestosis//Gestosis, Hypertension-Edema-Proteinuria//Hypertension Edema Proteinuria Gestosis//Toxemia Of Pregnancy//Of Pregnancies, Toxemia//Of Pregnancy, Toxemia//Pregnancies, Toxemia Of//Pregnancy, Toxemia Of//Toxemia Of Pregnancies//EPH Complex//EPH Toxemias//EPH Toxemia//Toxemia, EPH//Toxemias, EPH//EPH Gestosis//Gestosis, EPH//Toxemias, Pregnancy//Preeclampsia Eclampsia 1//1, Preeclampsia Eclampsia//1s, Preeclampsia Eclampsia//Eclampsia 1, Preeclampsia//Eclampsia 1s, Preeclampsia//Preeclampsia Eclampsia 1s//Proteinuria-Edema-Hypertension Gestosis//Gestosis, Proteinuria-Edema-Hypertension//Proteinuria Edema Hypertension Gestosis

 

Disease Association Statistics

Total Associated ncRNA Number:42   
More Information
Causal ncRNA Number:36
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
DLX6-AS1  (Score: 0.731059)
UCA1  (Score: 0.731059)
SNHG14  (Score: 0.731059)
APOA1-AS  (Score: 0.731059)
uc.187  (Score: 0.731059)
DANCR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//Transfection//Tube Formation Assay//Immunoblotting//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31774373
Disease Name:Pre-Eclampsia
Sample:placenta
Dysfunction Pattern:Regulation[ miR-206/IGF-1 axis]
Validated Method:Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:We found that MALAT1 was decreased but miR-206 was increased in the placenta of patients with PE.Further, miR-206 was confirmed as a direct target of MALAT1. Besides, miR-206 inhibited IGF-1 expression by directly binding to the 3'UTR. Mechanistically, our study demonstrated that MALAT1 regulates IGF-1/PI3K/Akt signaling via miR-206. Together, these results suggest that MALAT1 and miR-206 play important roles in PE. MALAT1 regulates miR-206/IGF-1 axis, thereby modulating trophoblast cells migration and invasion through PI3K/Akt signal pathway. These results show light on the underlying mechanisms of PE and provide potential targets for PE therapy.
Causality:Yes
Causal Description:Inhibition of MALAT1, knockdown IGF-1, or miR-206 mimics suppressed the trophoblast cells migration and invasion, while overexpression of MALAT1, IGF-1 or miR-206 inhibitors exhibited opposite effects.
Clinical-realted Application:

[2] PubMed ID:33547935
Disease Name:Pre-Eclampsia
Sample:placenta of patients with severe preeclampsia
Dysfunction Pattern:Expression [lower expressed]
Validated Method:Transfection//Tube Formation Assay//Immunoblotting//Migration Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay
Description:The expression of lncRNA MALAT1 was downregulated in the placenta of patients with severe preeclampsia. Moreover, MALAT1 inhibited the expression of angiogenic factors in umbilical vein endothelial cells co-cultured with trophoblasts.
Causality:Yes
Causal Description:MALAT1 smart silencer significantly inhibited HTR-8/SVneo trophoblast cell proliferation, invasion, migration and tube formation in vitro.
Clinical-realted Application: