Entry Detail

General Information

Database ID: LDA0001520
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8778D003424
Disease Name:Crohn's diseaseCrohn Disease
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:An intestinal disease that involves inflammation located_in intestine.A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Alias:Crohn disease//Crohn's disease of colon//Crohn's disease of large bowel//Granulomatous Colitis//Pediatric Crohn's diseaseCrohn Disease//Crohn's Enteritis//Regional Enteritis//Crohn's Disease//Crohns Disease//Inflammatory Bowel Disease 1//Enteritis, Granulomatous//Granulomatous Enteritis//Enteritis, Regional//Ileocolitis//Colitis, Granulomatous//Granulomatous Colitis//Ileitis, Terminal//Terminal Ileitis//Ileitis, Regional//Regional Ileitides//Regional Ileitis

 

Disease Association Statistics

Total Associated ncRNA Number:24   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
hsa_circ_102610  (Score: 0.985791)
hsa_circ_103124  (Score: 0.985791)
hsa_circ_102610  (Score: 0.985791)
hsa_circ_103124  (Score: 0.985791)
MALAT1  (Score: 0.731059)
PELATON  (Score: 0.731059)
hsa_circ_103765  (Score: 0.731059)
circGMCL1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
PELATON  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33677577
Disease Name:Crohn Disease
Sample:intestine mucosa of CD patients and mice
Dysfunction Pattern:Interaction(miR-146b-5p-CLDN11/NUMB Pathway)
Validated Method:Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Microarray
Description:MALAT1 was aberrantly downregulated in the intestine mucosa of CD patients and mice with experimental colitis. MALAT1 regulated the intestinal mucosal barrier and regained intestinal homeostasis by sequestering miR-146b-5p and maintaining the expression of the AJC proteins NUMB and CLDN11.
Causality:Yes
Causal Description:MALAT1 knockout mice were hypersensitive to DSS-induced experimental colitis.
Clinical-realted Application: