Entry Detail

General Information

Database ID: LDA0001523
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11714D016640
Disease Name:gestational diabetesDiabetes, Gestational
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A diabetes mellitus that manifests during pregnancy.Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.
Alias:GDM//Gestational diabetes mellitus//Maternal gestational diabetes mellitusDiabetes, Gestational//Diabetes, Pregnancy-Induced//Diabetes, Pregnancy Induced//Pregnancy-Induced Diabetes//Gestational Diabetes//Diabetes Mellitus, Gestational//Gestational Diabetes Mellitus

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.731059)
hsa_circ_0001578  (Score: 0.731059)
hsa_circ_0005243  (Score: 0.731059)
MALAT1  (Score: 0.731059)
hsa_circ_0001578  (Score: 0.731059)
hsa_circ_0005243  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//MTT//ELISA//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32783409
Disease Name:Diabetes, Gestational
Sample:Gestational diabetes mellitus placental tissues
Dysfunction Pattern:regulation[TGF-β/NF-κB signaling pathway]
Validated Method:Western Blot//qRT-PCR//MTT//ELISA//Transwell Assay
Description:Gestational diabetes mellitus placental tissues showed higher lncRNA MALAT1 expression compared to a normal control group (p < 0.05). Downregulation of lncRNA MALAT1 inhibits inflammation and suppresses the proliferation, invasion and migration of GDM placental trophoblastic cells, possibly by modulating the TGF-β/NF-κB signaling pathway.
Causality:Yes
Causal Description:After siRNA intervention, lncRNA MALAT1 showed decreased expression in the trophoblastic layer; inhibited trophoblastic cell proliferation, migration, or invasion; decreased the secretion of inflammatory factors TNF-α and IL-6; and suppressed the expression of TGF-β and NF-κB compared to that of the control and siRNA-NC groups (p < 0.05).
Clinical-realted Application: