Entry Detail

General Information

Database ID: LDA0001529
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11612D011085
Disease Name:polycystic ovary syndromePolycystic Ovary Syndrome
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Alias:Multicystic ovaries//PCOS//Polycystic Ovarian disease//Polycystic ovaries//Stein-Leventhal synd.//Stein-Leventhal syndrome//polycystic ovaryPolycystic Ovary Syndrome//Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:126   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
hsa_circ_0043532  (Score: 0.985791)
hsa_circ_0043532  (Score: 0.985791)
MALAT1  (Score: 0.731059)
BANCR  (Score: 0.731059)
LINC00477  (Score: 0.731059)
lncROR  (Score: 0.731059)
H19  (Score: 0.731059)
lnc-CCNL1-3:1  (Score: 0.731059)
GAS5  (Score: 0.731059)
lnc-MAP3K13-7:1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//Immunoblotting//Flow Cytometry//FISH//qRT-PCR//Cell Proliferation Assay//IP//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34883204
Disease Name:Polycystic Ovary Syndrome
Sample:cell line
Dysfunction Pattern:Interaction(MDM2)
Validated Method:Transfection//Immunoblotting//Flow Cytometry//FISH//qRT-PCR//Cell Proliferation Assay//IP//IF
Description:We identified that MALAT1 interacted with MDM2 and PARP1 in the cell nucleus. MDM2 binds to the 3' segment of MALAT1, containing the ENE domain through the ring finger domain.
Causality:Yes
Causal Description:Knockdown of MALAT1 in KGN cells and primary GCs increased apoptosis and reduced proliferation.
Clinical-realted Application: