Entry Detail

General Information

Database ID: LDA0001531
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007822
Disease Name:Laryngeal Neoplasms
Category:MeSH
Type:Neoplasms
Define:Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Alias:Laryngeal Neoplasms//Neoplasms, Laryngeal//Laryngeal Neoplasm//Neoplasm, Laryngeal//Larynx Neoplasms//Larynx Neoplasm//Neoplasm, Larynx//Neoplasms, Larynx//Cancer of Larynx//Larynx Cancers//Laryngeal Cancer//Cancer, Laryngeal//Cancers, Laryngeal//Laryngeal Cancers//Larynx Cancer//Cancer, Larynx//Cancers, Larynx//Cancer of the Larynx

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:40
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
PCAT19  (Score: 0.731059)
circRANBP9  (Score: 0.731059)
PCAT1  (Score: 0.731059)
SBF2-AS1  (Score: 0.731059)
CYTOR  (Score: 0.731059)
LINC00888  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34183954
Disease Name:Laryngeal Neoplasms
Sample:tissues and cell
Dysfunction Pattern:Interaction(miR-125b/HMGA1.)
Validated Method:Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description: In laryngocarcinoma tissues and cells, lncRNA MALAT1 expression was significantly increased compared to normal tissues and cells.LncRNA MALAT1 upregulates HMGA1 expression by acting as a competitive endogenous RNA (ceRNA) for miR-125b. Rescue experiments showed that microRNA-125b inhibitor reversed the change in cell viability and invasion induced by sh-MALAT1. Down regulation of lncRNA MALAT1 inhibits laryngocarcinoma proliferation and invasion by modulating miR-125b/HMGA1.
Causality:Yes
Causal Description:LncRNA MALAT1 promotes proliferation and migration of laryngocarcinoma cells.
Clinical-realted Application:

[2] PubMed ID:35601153
Disease Name:Laryngeal Neoplasms
Sample:laryngocarcinoma cells
Dysfunction Pattern:Interaction(miR-708-5p/BRD4 )
Validated Method:In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//Flow Cytometry//qRT-PCR//Transwell Assay
Description:MALAT1 suppression inhibited the malignant phenotypes of laryngocarcinoma cells, such as decreased proliferation, promoted apoptosis, suppressed migration, and inhibited the CSC properties.Suppression of MALAT1 increased miR-708-5p expression and decreased the expression of BRD4 and YAP1 and inhibited EMT. Moreover, there were target relationships between MALAT1 and miR-708-5p as well as between miR-708-5p and BRD4. miR-708-5p overexpression and MALAT1 suppression had synergistic inhibitory effects on the malignant phenotypes of laryngocarcinoma cells and the expression of BRD4, YAP1, and EMT.
Causality:Yes
Causal Description:MALAT1 suppression inhibited the malignant phenotypes of laryngocarcinoma cells, such as decreased proliferation, promoted apoptosis, suppressed migration, and inhibited the CSC properties.Furthermore, in vivo experiments confirmed that MALAT1/miR-708-5p regulated tumorigenicity by regulating BRD4 and YAP1-mediated EMT.
Clinical-realted Application: