Entry Detail

General Information

Database ID: LDA0001584
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LUNAR1
Full Name:leukemia-associated non-coding IGF1R activator RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):99014704End Site(bp):99031050
External Links:
Ensembl ID:ENSG00000278090
Ensembl Transcript ID:N/A
Entrez Gene:104564224.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31882986
Disease Name:Colorectal Neoplasms
Sample:CRC tissues
Dysfunction Pattern:Interaction[suppress IGF1]
Validated Method:CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Description:Significantly increased expression of LUNAR1 in clinical CRC specimens was detected compared with that in matching normal tissues.Moreover, the inhibition of LUNAR1 can significantly suppress IGF1 signalling in CRC.
Causality:Yes
Causal Description: The downregulation of LUNAR1 in SW620 cells inhibited cell proliferation, migration, invasion and tumour growth while inducing apoptosis.
Clinical-realted Application:LUNAR1 expression in CRC was found to be associated with the tumour aggressiveness, disease-free survival and overall survival of patients.

[2] PubMed ID:33300052
Disease Name:Colorectal Neoplasms
Sample:CRC tissues
Dysfunction Pattern:regulation[miR-495-3p/MYCBP axis]
Validated Method:Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Description:RT?qPCR and Pearson's correlation analysis revealed that LUNAR1 was highly expressed and was negatively associated with the overall survival of CRC patients.In conclusion, LUNAR1 accelerates CRC progression via the miR‑495‑3p/MYCBP axis, indicating that LUNAR1 may serve as a prognostic biomarker for CRC patients.
Causality:Yes
Causal Description:Moreover, CCK?8, clone formation, wound?healing migration, Transwell chamber and FACs assay analyses showed that LUNAR1 knockdown inhibited CRC cell proliferation, migration and invasion, while accelerating cell apoptosis.
Clinical-realted Application:RT?qPCR and Pearson's correlation analysis revealed that LUNAR1 was highly expressed and was negatively associated with the overall survival of CRC patients.