Entry Detail

General Information

Database ID: LDA0001648
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LUCAT1
Full Name:lung cancer associated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:SCAL1|SCAT5
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):91302986End Site(bp):91314402
External Links:
Ensembl ID:ENSG00000248323
Ensembl Transcript ID:N/A
Entrez Gene:100505994.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:50   
More Information
Causal Disease Number:42
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Carcinoma, Renal Cell  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Multiple Myeloma  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4467D002292
Disease Name:clear cell renal cell carcinomaCarcinoma, Renal Cell
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Alias:Clear cell carcinoma of kidney//clear cell kidney carcinoma//conventional (Clear cell) renal cell carcinoma//conventional renal cell carcinoma//renal clear cell carcinomaCarcinoma, Renal Cell//Carcinomas, Renal Cell//Renal Cell Carcinomas//Nephroid Carcinoma//Carcinoma, Nephroid//Nephroid Carcinomas//Adenocarcinoma Of Kidney//Adenocarcinoma Of Kidneys//Kidney, Adenocarcinoma Of//Renal Cell Carcinoma//Renal Cell Cancer//Cancer, Renal Cell//Renal Cell Cancers//Adenocarcinoma, Renal//Renal Adenocarcinoma//Renal Adenocarcinomas//Renal Carcinoma//Carcinoma, Renal//Renal Carcinomas//Adenocarcinoma, Renal Cell//Adenocarcinomas, Renal Cell//Renal Cell Adenocarcinoma//Renal Cell Adenocarcinomas//Chromophobe Renal Cell Carcinoma//Sarcomatoid Renal Cell Carcinoma//Papillary Renal Cell Carcinoma//Renal Cell Carcinoma, Papillary//Chromophil Renal Cell Carcinoma//Clear Cell Renal Cell Carcinoma//Grawitz Tumor//Tumor, Grawitz//Clear Cell Renal Carcinoma//Carcinoma, Hypernephroid//Hypernephroid Carcinoma//Hypernephroid Carcinomas//Hypernephroma//Hypernephromas//Collecting Duct Carcinoma (Kidney)//Carcinoma, Collecting Duct (Kidney)//Carcinomas, Collecting Duct (Kidney)//Collecting Duct Carcinomas (Kidney)//Collecting Duct Carcinoma of the Kidney//Renal Collecting Duct Carcinoma//Collecting Duct Carcinoma//Carcinoma, Collecting Duct//Carcinomas, Collecting Duct//Collecting Duct Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:458   
More Information
Causal ncRNA Number:316
Network:
Top Causal ncRNAs:
SNHG12  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
PVT1  (Score: 1)
PVT1  (Score: 1)
SNHG12  (Score: 1)
SNHG1  (Score: 0.999893)
SNHG1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
MIR4435-2HG  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Northern Blot//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30032137
Disease Name:Carcinoma, Renal Cell
Sample:ccRCC tissues
Dysfunction Pattern:Regulation[AKT/GSK-3β Signaling Pathway]
Validated Method:qRT-PCR//Western Blot
Description:We found that LUCAT1 was significantly upregulated in both clinical ccRCC tissues (n = 90) and TCGA ccRCC tissues (n = 448) compared with normal tissues.These findings indicate that the CXCL2/LUCAT1/AKT/GSK-3β axis is a potential therapeutic target and molecular biomarker for ccRCC.
Causality:Yes
Causal Description: LUCAT1 knockdown inhibited ccRCC cell proliferation and colony formation, induced cell cycle arrest at G1 phase, and inhibited cell migration and invasion. Overexpression of LUCAT1 promoted proliferation, migration, and invasion of ccRCC cells.
Clinical-realted Application:Statistical analysis revealed that the LUCAT1 expression level positively correlated with tumor T stage (P < 0.01), M stage (P < 0.01), and TNM stage (P < 0.01). Overall survival and disease-free survival time were significantly shorter in the high-LUCAT1-expression group than in the low-LUCAT1-expression group (log-rank P < 0.01).

[2] PubMed ID:34035851
Disease Name:Carcinoma, Renal Cell
Sample:ccRCC tissues and cells
Dysfunction Pattern:Interaction(microRNA-375/YAP1 axis)
Validated Method:Northern Blot//Western Blot//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Invasion Assay
Description:The results revealed that LUCAT1 and YAP1 were upregulated and miR-375 was downregulated in ccRCC tissues and cells. LUCAT1 knockdown suppressed cell proliferation, migration and invasion, which were reversed by the inhibition of miR-375.
Causality:Yes
Causal Description:LUCAT1 knockdown suppressed cell proliferation, migration and invasion, which were reversed by the inhibition of miR-375.
Clinical-realted Application: