Entry Detail

General Information

Database ID: LDA0001652
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LUCAT1
Full Name:lung cancer associated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:SCAL1|SCAT5
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):91302986End Site(bp):91314402
External Links:
Ensembl ID:ENSG00000248323
Ensembl Transcript ID:N/A
Entrez Gene:100505994.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:50   
More Information
Causal Disease Number:42
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Carcinoma, Renal Cell  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Multiple Myeloma  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:687D018197
Disease Name:hepatoblastomaHepatoblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
Alias:Hepatoblastoma//Hepatoblastomas

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 0.731059)
LINC00205  (Score: 0.731059)
GAS5  (Score: 0.731059)
LUCAT1  (Score: 0.731059)
LINC01023  (Score: 0.731059)
circHMGCS1  (Score: 0.731059)
circSETD3  (Score: 0.731059)
hsa_circ_0000594  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MIR210HG  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30479162
Disease Name:Hepatoblastoma
Sample:HB tissues, cell lines
Dysfunction Pattern:Regulation[miR-301b/STAT3 axis]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP//Western Blot
Description:Quantitative reverse transcription polymerase chain reaction analysis showed that LUCAT1 was highly expressed in both HB tissues and cell lines. Luciferase assays indicated that STAT3 was a transcription activator of LUCAT1 and that LUCAT1 could increase STAT3 expression by competitively binding to miR-301b.
Causality:Yes
Causal Description:Loss-of function assays to identify the biological function of LUCAT1 in HB showed that LUCAT1 knockExpression[down-expression] inhibited cell proliferation, migration, and invasion but reversed epithelial-mesenchymal transition.
Clinical-realted Application: