Entry Detail

General Information

Database ID: LDA0001663
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013953
Disease Name:Thymus Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the THYMUS GLAND.
Alias:Thymus Neoplasms//Neoplasm, Thymus//Thymus Neoplasm//Thymus Tumors//Thymus Tumor//Tumor, Thymus//Tumors, Thymus//Thymic Neoplasms//Thymic Tumors//Thymic Tumor//Tumor, Thymic//Tumors, Thymic//Neoplasms, Thymic//Neoplasm, Thymic//Thymic Neoplasm//Neoplasms, Thymus//Cancer of Thymus//Thymus Cancers//Thymic Cancer//Cancer, Thymic//Cancers, Thymic//Thymic Cancers//Thymus Cancer//Cancer, Thymus//Cancers, Thymus//Cancer of the Thymus

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34122636
Disease Name:Thymus Neoplasms
Sample:cells
Dysfunction Pattern:Interaction(miR-145-5p/HMGA2 pathway)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Description:Among the four cell lines evaluated, IU-TAB-1 showed the highest expression of MALAT1; thus, IU-TAB-1 cells were selected for subsequent experiments. After treatment with si-MALAT1 in combination with miR-145-5p mimics or inhibitors, cell proliferation and apoptosis were respectively enhanced and inhibited in IU-TAB-1 cells. miR-145-5p inhibited the luciferase activity of IU-TAB-1 cells transfected with the MALAT1 or HMGA2 3' untranslated region. In conclusion, si-MALAT1 significantly attenuated cell proliferation and apoptosis via the miR-145-5p/HMGA2 pathway in thymic cancer cells.
Causality:Yes
Causal Description: Compared with the findings in the control group, si-MALAT1 significantly decreased the cell proliferation of IU-TAB-1 cells, whereas the apoptosis levels and number of cells in G2 phase were increased. The protein expression levels of cyclin D1, cyclin E, Bcl-2 and HMGA2 were significantly decreased in the si-MALAT1 group compared with those in the control group, while Bax levels were significantly increased.
Clinical-realted Application: