Entry Detail

General Information

Database ID: LDA0001665
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D055113
Disease Name:Chronic Periodontitis
Category:MeSH
Type:Stomatognathic Diseases
Define:Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.
Alias:Chronic Periodontitis//Chronic Periodontitides//Periodontitides, Chronic//Periodontitis, Adult//Periodontitis, Chronic//Adult Periodontitis//Adult Periodontitides//Periodontitides, Adult

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:33604388
Disease Name:Chronic Periodontitis
Sample:PDLCs
Dysfunction Pattern:Interaction(miR-769-5p/HIF3A Axis)
Validated Method:Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//ELISA
Description:The expression of MALAT1 and HIF3A was enhanced, and the expression of miR-769-5p was reduced in gingival tissues of patients with CP and LPS-treated PDLCs. MALAT1 knockdown promoted cell viability and inhibited inflammation and cell apoptosis in LPS-treated PDLCs. MALAT1 targeted miR-769-5p and negatively regulated miR-769-5p expression. miR-769-5p overexpression promoted cell viability and inhibited inflammation and cell apoptosis in LPS-treated PDLCs. Besides, miR-769-5p targeted HIF3A and negatively modulated HIF3A expression. Both miR-769-5p inhibition and HIF3A overexpression reversed the inhibitory effects of MALAT1 silencing on LPS-induced PDLC injury in vitro.
Causality:Yes
Causal Description:MALAT1 knockdown promoted cell viability and inhibited inflammation and cell apoptosis in LPS-treated PDLCs.
Clinical-realted Application: