Entry Detail

General Information

Database ID: LDA0001672
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0060061D016410
Disease Name:primary cutaneous T-cell non-Hodgkin lymphomaLymphoma, T-Cell, Cutaneous
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A non-Hodgkin's lymphoma that has_material_basis_in a mutation of T cells.A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
Alias:cutaneous T-cell lymphomaLymphoma, T-Cell, Cutaneous//Lymphoma, T Cell, Cutaneous//T-Cell Lymphoma, Cutaneous//T Cell Lymphoma, Cutaneous//Cutaneous T-Cell Lymphoma//Cutaneous T Cell Lymphoma//Cutaneous T-Cell Lymphomas//Lymphoma, Cutaneous T-Cell//Lymphomas, Cutaneous T-Cell//T-Cell Lymphomas, Cutaneous//Granulomatous Slack Skin//Slack Skin, Granulomatous

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Cell Proliferation Assay//qRT-PCR//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:36059695
Disease Name:Lymphoma, T-Cell, Cutaneous
Sample:CTCL cells
Dysfunction Pattern:Interaction(miR-124)
Validated Method:Cell Proliferation Assay//qRT-PCR//ELISA
Description:CTCL patients had higher circulating levels of IL-6, IL-8, IL-10, TGFβ, PGE2 and MMP7 which are factors released by tumor-associated macrophages in tumor microenvironment. MALAT1 sponged miR-124 as this tumor suppressive miRNA was de-repressed upon MALAT1 silencing. Moreover, downregulation of miR-124 attenuated MALAT1 silencing effects. Our study provides a rationale for further studies focused on an evaluation of MALAT1-miR-124 in CTCL progression.
Causality:Yes
Causal Description:Such silencing of MALAT1 resulted in reversal of EMT and inhibition of cancer stem cell phenotype, along with reduced cell growth and proliferation.
Clinical-realted Application: