Entry Detail

General Information

Database ID: LDA0001682
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D001171
Disease Name:Arthritis, Juvenile
Category:MeSH
Type:Musculoskeletal Diseases
Define:Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
Alias:Arthritis, Juvenile//Juvenile Arthritis//Childhood Arthritis//Arthritides, Childhood//Arthritis, Childhood//Childhood Arthritides//Arthritis, Juvenile Chronic//Juvenile Chronic Arthritis//Chronic Arthritis, Juvenile//Juvenile Idiopathic Arthritis//Idiopathic Arthritis, Juvenile//Arthritis, Juvenile Idiopathic//Juvenile Rheumatoid Arthritis//Arthritis, Juvenile Rheumatoid//Rheumatoid Arthritis, Juvenile//Oligoarthritis, Juvenile//Juvenile Oligoarthritis//Psoriatic Arthritis, Juvenile//Arthritis, Juvenile Psoriatic//Juvenile Psoriatic Arthritis//Enthesitis-Related Arthritis, Juvenile//Arthritis, Juvenile Enthesitis-Related//Enthesitis Related Arthritis, Juvenile//Juvenile Enthesitis-Related Arthritis//Polyarthritis, Juvenile, Rheumatoid Factor Negative//Juvenile-Onset Still Disease//Juvenile Onset Still Disease//Still Disease, Juvenile-Onset//Still Disease, Juvenile Onset//Still's Disease, Juvenile-Onset//Juvenile-Onset Still's Disease//Still's Disease, Juvenile Onset//Systemic Arthritis, Juvenile//Arthritis, Juvenile Systemic//Juvenile Systemic Arthritis//Juvenile-Onset Stills Disease//Juvenile Onset Stills Disease//Stills Disease, Juvenile-Onset//Polyarthritis, Juvenile, Rheumatoid Factor Positive//Polyarticular Juvenile Idiopathic Arthritis//Polyarticular-Course Juvenile Idiopathic Arthritis//PCJIA//PJIA Polyarticular Juvenile Idiopathic Arthritis

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:33341002
Disease Name:Arthritis, Juvenile
Sample:sJIA patients
Dysfunction Pattern:Interaction(miR-150-5p/ZBTB4 / JAK/STAT signal pathway)
Validated Method:Western Blot//Transfection//qRT-PCR//RIP//Luciferase Report Assay//ELISA
Description: We found that the expression of MALAT1, the plasma level of pro-inflammatory cytokines (IL-6, IL-17, IL-1β, and TNF-α) as well as MMP-8 and MMP-9 production were significantly elevated in sJIA patients.Furthermore, bioinformatics analysis predicted that MALAT1 might bind to miR-150-5p and ZBTB4 was a downstream target gene of miR-150-5p. Besides, rescue assays revealed that MALAT1 knockdown-mediated suppressive effects on cytokine production could be reversed by ZBTB4 overexpression. In addition, MALAT1 activated the JAK/STAT signaling by upregulating ZBTB4 expression.
Causality:Yes
Causal Description:Moreover, we observed that the production of these cytokines in peripheral blood mononuclear cells (PBMCs) from sJIA patients were reduced after MALAT1 knockdown.
Clinical-realted Application: