Entry Detail

General Information

Database ID: LDA0001761
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00525
Full Name:long intergenic non-protein coding RNA 525
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):47761476End Site(bp):47766772
External Links:
Ensembl ID:ENSG00000146666
Ensembl Transcript ID:N/A
Entrez Gene:84847.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
spinal chordoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
spinal chordoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4153
Disease Name:spinal chordoma
Category:Disease Ontology
Type:Nervous System Diseases
Define:A chordoma that derives_from the spine.
Alias:Chordoma of Spine

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
LINC00525  (Score: 0.731059)
LINC00525  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33370717
Disease Name:spinal chordoma
Sample:spinal chordoma tissues
Dysfunction Pattern:interaction[ targeted miR-31-5p and miR-125a-5p]
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Description: After LINC00525 was downregulated in spinal chordoma cells, there were inhibitory effects on cell proliferation, migration, invasion and EMT but a promoting effect on cell apoptosis.All these results suggested that LINC00525 targeted miR-31-5p and miR-125a-5p to promote the tumorigenesis and progression of spinal chordoma.
Causality:Yes
Causal Description:Tumorigenesis of spinal chordoma in vivo was also inhibited by knockdown of LINC00525 via the promotion of miR-31-5p and miR-125a-5p.
Clinical-realted Application: