Entry Detail

General Information

Database ID: LDA0001763
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00612
Full Name:long intergenic non-protein coding RNA 612
Category:LncRNA
Species:Homo sapiens
Synonyms:C12orf33
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):9055589End Site(bp):9065070
External Links:
Ensembl ID:ENSG00000214851
Ensembl Transcript ID:N/A
Entrez Gene:253128.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Urinary Bladder Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11054D001749
Disease Name:urinary bladder cancerUrinary Bladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An urinary system cancer that results_in malignant growth located_in the urinary bladder.Tumors or cancer of the URINARY BLADDER.
Alias:bladder cancer//tumor of the bladderUrinary Bladder Neoplasms//Neoplasm, Urinary Bladder//Urinary Bladder Neoplasm//Bladder Tumors//Bladder Tumor//Tumor, Bladder//Tumors, Bladder//Neoplasms, Bladder//Bladder Neoplasms//Bladder Neoplasm//Neoplasm, Bladder//Urinary Bladder Cancer//Cancer, Urinary Bladder//Malignant Tumor of Urinary Bladder//Cancer of the Bladder//Bladder Cancer//Bladder Cancers//Cancer, Bladder//Cancer of Bladder

 

Disease Association Statistics

Total Associated ncRNA Number:604   
More Information
Causal ncRNA Number:428
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
TINCR  (Score: 0.999893)
PCAT6  (Score: 0.999893)
GAS5  (Score: 0.999893)
MILIP  (Score: 0.999893)
TUG1  (Score: 0.999893)
circCEP128  (Score: 0.999893)
XIST  (Score: 0.999893)
CASC9  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//FISH//qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30940184
Disease Name:Urinary Bladder Neoplasms
Sample:BC tissues and cell lines
Dysfunction Pattern:Interaction[sponging miR-590 to upregulate PHF14]
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//FISH//Luciferase Report Assay
Description:LINC00612 was upregulated in BC tissues and cell lines.Our results indicate that LINC00612 enhances the proliferation and invasion ability of BC cells by sponging miR-590 to upregulate PHF14 expression and promote BC cellular EMT, suggesting that LINC00612 may act as a potential biomarker and therapeutic target for BC.
Causality:Yes
Causal Description:Functionally, downregulation of LINC00612 inhibited cell proliferation and invasion in vitro and in vivo, whereas overexpression of LINC00612 resulted in the opposite effects.
Clinical-realted Application: