Entry Detail

General Information

Database ID: LDA0001764
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00612
Full Name:long intergenic non-protein coding RNA 612
Category:LncRNA
Species:Homo sapiens
Synonyms:C12orf33
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):9055589End Site(bp):9065070
External Links:
Ensembl ID:ENSG00000214851
Ensembl Transcript ID:N/A
Entrez Gene:253128.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Urinary Bladder Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3347D012516
Disease Name:osteosarcomaOsteosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Alias:Osteogenic sarcoma//Skeletal sarcoma//bone tissue neoplasm//osteoid sarcomaOsteosarcoma//Osteosarcomas//Osteosarcoma Tumor//Osteosarcoma Tumors//Tumor, Osteosarcoma//Tumors, Osteosarcoma//Sarcoma, Osteogenic//Osteogenic Sarcomas//Sarcomas, Osteogenic//Osteogenic Sarcoma

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:600
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
PVT1  (Score: 1)
GAS5  (Score: 1)
SNHG16  (Score: 1)
LINC00662  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00662  (Score: 1)
ZFAS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32311343
Disease Name:Osteosarcoma
Sample:osteosarcoma cells
Dysfunction Pattern:interaction[miR-214-5p]
Validated Method:Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay//Transwell Assay
Description:LINC00612 was found to be significantly upregulated in osteosarcoma cells and metastatic osteosarcoma. Our study shows that LINC00612 plays an important role in regulating the proliferation and invasion of osteosarcoma by endogenously competing with miR-214-5p and mediating EMT.
Causality:Yes
Causal Description: LINC00612 overexpression promoted the proliferation, invasion and in vivo explant growth of osteosarcoma.
Clinical-realted Application: