Entry Detail

General Information

Database ID: LDA0001765
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00607
Full Name:long intergenic non-protein coding RNA 607
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):215611563End Site(bp):215843536
External Links:
Ensembl ID:ENSG00000235770
Ensembl Transcript ID:N/A
Entrez Gene:646324.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3347D012516
Disease Name:osteosarcomaOsteosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Alias:Osteogenic sarcoma//Skeletal sarcoma//bone tissue neoplasm//osteoid sarcomaOsteosarcoma//Osteosarcomas//Osteosarcoma Tumor//Osteosarcoma Tumors//Tumor, Osteosarcoma//Tumors, Osteosarcoma//Sarcoma, Osteogenic//Osteogenic Sarcomas//Sarcomas, Osteogenic//Osteogenic Sarcoma

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:600
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
PVT1  (Score: 1)
GAS5  (Score: 1)
SNHG16  (Score: 1)
LINC00662  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00662  (Score: 1)
ZFAS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Flow Cytometry//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33585204
Disease Name:Osteosarcoma
Sample:cell lines
Dysfunction Pattern:interaction[ miR-607,E2F6 ]
Validated Method:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//CCK8//FISH//Luciferase Report Assay//Colony Formation Assay
Description:Based on the RNA-sequencing results, LINC00607 expression was significantly upregulated in pulmonary metastasis within OS. This work revealed that LINC00607 worked as an miR-607 sponge to upregulate E2F6 expression, which promoted tumor proliferation in OS.
Causality:Yes
Causal Description:Functional experiments revealed that LINC00607 promoted migration and invasion of endothelial cells to exacerbate epithelial-mesenchymal transition (EMT). Finally, we found that LINC00607 promoted OS progression in vivo.
Clinical-realted Application: