Entry Detail

General Information

Database ID: LDA0001785
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00649
Full Name:long intergenic non-protein coding RNA 649
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00650|lnc-ITSN1-2
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):33931122End Site(bp):33971186
External Links:
Ensembl ID:ENSG00000237945
Ensembl Transcript ID:N/A
Entrez Gene:100506334.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
lung squamous cell carcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
lung squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35228660
Disease Name:lung squamous cell carcinoma
Sample:LUSC cells
Dysfunction Pattern:Interaction(E2F7/LINC00649/TAF15/MAPK6/MAPK signaling pathway)
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Description: As a result, LINC00649 was discovered to be with high expression in LUSC cells. Results of mechanism assays validated that E2F transcription factor 7 (E2F7) was a transcription activator of LINC00649 and induced its up-regulation in LUSC cells. Furthermore, LINC00649 recruited TAF15, which is TATA-box binding protein associated factor 15 to stabilize mitogen-activated protein kinase 6 (MAPK6) expression and activate the transcription of MAPK6, thereby enhancing MAPK6 expression to activate the MAPK signaling pathway. In summary, our research determined the E2F7/LINC00649/TAF15/MAPK6/MAPK signaling pathway in regulating LUSC development, which made LINC00649 a potential biomarker for LUSC treatment.
Causality:Yes
Causal Description:Moreover, it was confirmed through functional assays that the knockdown of LINC00649 hindered the occurrence and progression of LUSC.
Clinical-realted Application: