Entry Detail

General Information

Database ID: LDA0001821
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00922
Full Name:long intergenic non-protein coding RNA 922
Category:LncRNA
Species:Homo sapiens
Synonyms:Lnc-LALC
Chromosome:16
Strand:-
Coordinate:
Start Site(bp):65284502End Site(bp):65576297
External Links:
Ensembl ID:ENSG00000261742
Ensembl Transcript ID:N/A
Entrez Gene:283867.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
Colorectal Cancer Liver Metastasis  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
Colorectal Cancer Liver Metastasis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerBreast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

 

Disease Association Statistics

Total Associated ncRNA Number:1186   
More Information
Causal ncRNA Number:766
Network:
Top Causal ncRNAs:
MILIP  (Score: 1)
GAS5  (Score: 1)
MILIP  (Score: 1)
H19  (Score: 1)
CDKN2B-AS1  (Score: 1)
DANCR  (Score: 1)
AFAP1-AS1  (Score: 1)
CDKN2B-AS1  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RIP//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33045317
Disease Name:Breast Neoplasms
Sample:Breast cancer tissues
Dysfunction Pattern:regulation[promoting NKD2 methylation]
Validated Method:qRT-PCR//RIP//ChIP
Description:The RNA extraction and quantification and immunohistochemical staining characterized the high expression of LINC00922 and low expression of NKD2 in breast cancer tissues in comparison to its adjacent counterparts. The current study provides evidence that LINC00922 acts as a tumor promoter by promoting NKD2 methylation. Hopefully, it provides a novel potential gene target for the treatment of breast cancer.
Causality:Yes
Causal Description:The ectopically expressed LINC00922 activated the Wnt signaling pathway, promoted epithelial-mesenchymal transition, cell proliferative, invasive and migratory capacities, tumor growth and metastasis.
Clinical-realted Application: