Entry Detail

General Information

Database ID: LDA0001823
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00922
Full Name:long intergenic non-protein coding RNA 922
Category:LncRNA
Species:Homo sapiens
Synonyms:Lnc-LALC
Chromosome:16
Strand:-
Coordinate:
Start Site(bp):65284502End Site(bp):65576297
External Links:
Ensembl ID:ENSG00000261742
Ensembl Transcript ID:N/A
Entrez Gene:283867.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
Colorectal Cancer Liver Metastasis  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
Colorectal Cancer Liver Metastasis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3571D008113
Disease Name:liver cancerLiver Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A hepatobiliary system cancer that is located_in the liver.Tumors or cancer of the LIVER.
Alias:Ca liver - primary//Resectable malignant neoplasm of Liver//hepatic cancer//hepatic neoplasm//malignant hepato-biliary neoplasm//malignant neoplasm of liver//malignant neoplasm of liver, not specified as primary or secondary//malignant neoplasm of liver, primary//malignant tumor of liver//neoplasm of liver//non-resectable primary hepatic malignant neoplasm//primary liver cancer//primary malignant neoplasm of liver//resectable malignant neoplasm of the liverLiver Neoplasms//Neoplasms, Hepatic//Neoplasms, Liver//Liver Neoplasm//Neoplasm, Liver//Hepatic Neoplasms//Hepatic Neoplasm//Neoplasm, Hepatic//Cancer of Liver//Hepatocellular Cancer//Cancers, Hepatocellular//Hepatocellular Cancers//Hepatic Cancer//Cancer, Hepatic//Cancers, Hepatic//Hepatic Cancers//Liver Cancer//Cancer, Liver//Cancers, Liver//Liver Cancers//Cancer of the Liver//Cancer, Hepatocellular

 

Disease Association Statistics

Total Associated ncRNA Number:162   
More Information
Causal ncRNA Number:138
Network:
Top Causal ncRNAs:
SNHG1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
CEBPA-DT  (Score: 0.985791)
CEBPA-DT  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
BCAR4  (Score: 0.985791)
BCAR4  (Score: 0.985791)
SNHG1  (Score: 0.985791)
HULC  (Score: 0.985791)
GAS5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34097192
Disease Name:Liver Neoplasms
Sample:HCC tissues
Dysfunction Pattern:Interaction(miR-424-5p/ARK5)
Validated Method:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Bioinformatics Analysis//Transwell Assay
Description: MiR-424-5p was low expressed, whereas LINC00922 and ARK5 were high expressed in HCC tissues. MiR-424-5p was negatively associated with LINC00922 and ARK5 that was positively associated with LINC00922. Interestingly, LINC00922 partially shared an identical binding site of miR-424-5p with ARK5.
Causality:Yes
Causal Description: LINC00922 its overexpression partially offset the inhibitory effect of miR-424-5p on cancer cell functions. ARK5 silencing repressed the malignant phenotype of cancer cells and inhibited the expressions of epithelial-to-mesenchymal transition (EMT)-related molecules (Vimentin, Snail and N-Cadherin). However, these effects were partially neutralized by miR-424-5p inhibitors.
Clinical-realted Application: