Entry Detail

General Information

Database ID: LDA0001836
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00857
Full Name:long intergenic non-protein coding RNA 857
Category:LncRNA
Species:Homo sapiens
Synonyms:HUMT
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):80207710End Site(bp):80219657
External Links:
Ensembl ID:ENSG00000237523
Ensembl Transcript ID:N/A
Entrez Gene:439990.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Pancreatic Neoplasms  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
pancreatic adenocarcinoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4074
Disease Name:pancreatic adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
Alias:pancreas adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
CCHE1  (Score: 0.731059)
circMYBL2  (Score: 0.731059)
LINC01139  (Score: 0.731059)
LINC01857  (Score: 0.731059)
LINC00857  (Score: 0.731059)
lnc-IUR  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33661995
Disease Name:pancreatic adenocarcinoma
Sample:pancreatic adenocarcinoma cells
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR//Luciferase Report Assay
Description: LINC00857 upregulation promoted the proliferation and clone formation abilities of PAAD cells. Afterwards, the downstream miRNA and mRNA targets of LINC00857 were picked up to construct a ceRNA network. Further study revealed that TGFA expression was positively regulated by LINC00857 and negatively regulated by miR-340-5p. Besides that, the inhibitory effect of miR-340-5p on PAAD cells growth and movement can be blocked by LINC00857 upregulation.
Causality:Yes
Causal Description:the malignant behavior of PAAD cells induced by TGFA overexpression can be eliminated by LINC00857 knockdown.
Clinical-realted Application:By enquiring TCGA database, we got that LINC00857 was highly expressed in patients with PAAD and positively associated with worse prognosis in PAAD patients.