Entry Detail

General Information

Database ID: LDA0001839
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00680
Full Name:long intergenic non-protein coding RNA 680
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):57945834End Site(bp):57961446
External Links:
Ensembl ID:ENSG00000215190
Ensembl Transcript ID:N/A
Entrez Gene:106660612.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Adenocarcinoma of Lung  (Score: 0.731059)
Myasthenia Gravis  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Myasthenia Gravis  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:437D009157
Disease Name:myasthenia gravisMyasthenia Gravis
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath.A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
Alias:Myasthenia Gravis//Myasthenia Gravis, Ocular//Ocular Myasthenia Gravis//Myasthenia Gravis, Generalized//Generalized Myasthenia Gravis//Muscle-Specific Receptor Tyrosine Kinase Myasthenia Gravis//Muscle Specific Receptor Tyrosine Kinase Myasthenia Gravis//Muscle-Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis//Muscle Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis//MuSK MG//MuSK Myasthenia Gravis//Myasthenia Gravis, MuSK//Anti-MuSK Myasthenia Gravis//Anti MuSK Myasthenia Gravis//Myasthenia Gravis, Anti-MuSK

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
LINC00680  (Score: 0.731059)
circFBL  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
LINC00680  (Score: 0.731059)
circFBL  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35800083
Disease Name:Myasthenia Gravis
Sample:peripheral blood mononuclear cells of patients with MG
Dysfunction Pattern:Interaction(miR-320a/MAPK1)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Bioinformatics Analysis
Description:Compared with control subjects, the expression levels of LINC00680 and mitogen-activated protein kinase 1 (MAPK1) in peripheral blood mononuclear cells of patients with MG were both upregulated; the levels of miR-320a were downregulated. A positive correlation was detected between LINC00680 expression and the severity of MG. Luciferase reporter assays identified that LINC00680 acts as a target for miR-320a. The in vitro analysis confirmed that LINC00680 regulates the expression of MAPK1 by sponging miR-320a. Finally, the functional analysis indicated that LINC00680 promoted Jurkat cell proliferation and inhibited cellular apoptosis by sponging miR-320a.
Causality:Yes
Causal Description:Finally, the functional analysis indicated that LINC00680 promoted Jurkat cell proliferation and inhibited cellular apoptosis by sponging miR-320a.
Clinical-realted Application: