Entry Detail

General Information

Database ID: LDA0001858
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00839
Full Name:long intergenic non-protein coding RNA 839
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):42475491End Site(bp):42495337
External Links:
Ensembl ID:ENSG00000185904
Ensembl Transcript ID:N/A
Entrez Gene:84856.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Neuroblastoma  (Score: 0.985791)
Neuroblastoma  (Score: 0.985791)
Lung Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:769D009447
Disease Name:neuroblastomaNeuroblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An autonomic nervous system neoplasm that derives_from immature nerve cells.A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Alias:Neuroblastoma//Neuroblastomas

 

Disease Association Statistics

Total Associated ncRNA Number:98   
More Information
Causal ncRNA Number:60
Network:
Top Causal ncRNAs:
SNHG16  (Score: 1)
SNHG16  (Score: 1)
DUXAP9  (Score: 0.999893)
DLX6-AS1  (Score: 0.999893)
DLX6-AS1  (Score: 0.999893)
DUXAP9  (Score: 0.999893)
LINC00839  (Score: 0.985791)
SNHG7  (Score: 0.985791)
SNHG7  (Score: 0.985791)
LINC00839  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//IHC//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35606572
Disease Name:Neuroblastoma
Sample:NB tumor tissues and cells
Dysfunction Pattern:Regulation(miR-454-3p to Up-Regulate NEUROD1)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining
Description:LINC00839 was found as a potential driver of NB progression. LINC00839 expression was higher in NB tumor tissues and cells. Also, LINC00839 expression was positively correlated with MYCN amplification, advanced INSS stages, and worse prognosis. Silencing of LINC00839 suppressed cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro. Mechanistically, LINC00839 could act as a sponge of miR-454-3p to facilitate the expression of its target NEUROD1. Moreover, miR-454-3p was demonstrated to exert an anti-cancer activity in NB. More importantly, the tumor-suppressive properties mediated by LINC00839 knockdown were significantly counteracted by the inhibition of miR-454-3p or overexpression of NEUROD1. Our study demonstrates that LINC00839 exerts an oncogenic role in NB through sponging miR-454-3p to up-regulate NEUROD1 expression, deepening our comprehension of lncRNA involved in NB and providing access to the possibility of LINC00839 as a therapeutic target for NB.
Causality:Yes
Causal Description:Silencing of LINC00839 suppressed cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro. Mechanistically, LINC00839 could act as a sponge of miR-454-3p to facilitate the expression of its target NEUROD1.
Clinical-realted Application:Also, LINC00839 expression was positively correlated with MYCN amplification, advanced INSS stages, and worse prognosis.

[2] PubMed ID:34188473
Disease Name:Neuroblastoma
Sample:neuroblastoma tissues and cell lines
Dysfunction Pattern:Interaction(miR-338-3p/GLUT1 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:LINC00839 and GLUT1 abundances were increased in neuroblastoma tissues and cell lines. The high expression of LINC00839 and GLUT1 indicated the lower overall survival. LINC00839 interference constrained neuroblastoma cell proliferation, migration, invasion and glycolysis, and facilitated apoptosis. GLUT1 overexpression or miR-338-3p knockdown could mitigate the influence of LINC00839 silence on neuroblastoma cell processes. LINC00839 could regulate GLUT1 expression via miR-338-3p. LINC00839 knockdown reduced neuroblastoma cell growth in xenograft model.
Causality:Yes
Causal Description:GLUT1 overexpression or miR-338-3p knockdown could mitigate the influence of LINC00839 silence on neuroblastoma cell processes. LINC00839 could regulate GLUT1 expression via miR-338-3p. LINC00839 knockdown reduced neuroblastoma cell growth in xenograft model.
Clinical-realted Application:The high expression of LINC00839 and GLUT1 indicated the lower overall survival.