Entry Detail

General Information

Database ID: LDA0001864
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00839
Full Name:long intergenic non-protein coding RNA 839
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):42475491End Site(bp):42495337
External Links:
Ensembl ID:ENSG00000185904
Ensembl Transcript ID:N/A
Entrez Gene:84856.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Neuroblastoma  (Score: 0.985791)
Neuroblastoma  (Score: 0.985791)
Lung Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1324D008175
Disease Name:lung cancerLung Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A respiratory system cancer that is located_in the lung.Tumors or cancer of the LUNG.
Alias:Lung Neoplasms//Pulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:344   
More Information
Causal ncRNA Number:282
Network:
Top Causal ncRNAs:
OIP5-AS1  (Score: 0.999893)
OIP5-AS1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
circHIPK3  (Score: 0.985791)
GAS5  (Score: 0.985791)
PCAT1  (Score: 0.985791)
NNT-AS1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34734406
Disease Name:Lung Neoplasms
Sample:LC cells
Dysfunction Pattern:Interaction(miR-519d-3p/JMJD6 axis )
Validated Method:Western Blot//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Invasion Assay//Transwell Assay
Description:LINC00839 was upregulated in LC cells and its knockdown resulted in reduced cell viability, migratory ability and invasion with increased cell apoptosis.MiR-519d-3p was the target gene of LINC00839 and its expression was reduced by LINC00839 overexpression. JMJD6 was directly targeted and suppressed at the level of mRNA and protein expression by miR-519d-3p.
Causality:Yes
Causal Description:LINC00839 was upregulated in LC cells and its knockdown resulted in reduced cell viability, migratory ability and invasion with increased cell apoptosis.
Clinical-realted Application: