LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0001879
Species:	Homo sapiens
Confidence Score:	0.999893
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Yes

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

LINC00460

Full Name:

long intergenic non-protein coding RNA 460

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

Chromosome:

Strand:

Coordinate:

Start Site(bp):

106376564

End Site(bp):

106378595

External Links:

Ensembl ID:	ENSG00000233532
Ensembl Transcript ID:	N/A
Entrez Gene:	728192.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

34 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Colorectal Neoplasms (Score: 1)

Carcinoma, Hepatocellular (Score: 0.999893)

Thyroid Cancer, Papillary (Score: 0.999893)

Pancreatic Neoplasms (Score: 0.999893)

Carcinoma, Hepatocellular (Score: 0.999893)

Thyroid Cancer, Papillary (Score: 0.999893)

Squamous Cell Carcinoma of Head and Neck (Score: 0.985791)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:		D000077273
Disease Name:		Thyroid Cancer, Papillary
Category:		MeSH
Type:		Neoplasms
Define:		An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.
Alias:		Thyroid Cancer, Papillary//Cancer, Papillary Thyroid//Cancers, Papillary Thyroid//Papillary Thyroid Cancer//Papillary Thyroid Cancers//Thyroid Cancers, Papillary//Thyroid Carcinoma, Papillary//Carcinoma, Papillary Thyroid//Carcinomas, Papillary Thyroid//Papillary Thyroid Carcinomas//Thyroid Carcinomas, Papillary//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Carcinoma, Nonmedullary Thyroid//Carcinomas, Nonmedullary Thyroid//Nonmedullary Thyroid Carcinomas//Thyroid Carcinoma, Nonmedullary//Thyroid Carcinomas, Nonmedullary

Disease Association Statistics

Total Associated ncRNA Number:

340 More Information

Causal ncRNA Number:

280

Network:

Top Causal ncRNAs:

UCA1 (Score: 0.999893)

HOTAIR (Score: 0.999893)

LINC00460 (Score: 0.999893)

HOTAIR (Score: 0.999893)

LINC00460 (Score: 0.999893)

BICDL3P (Score: 0.999358)

hsa_circ_0000644 (Score: 0.985791)

circRAPGEF5 (Score: 0.985791)

More Information

Evidence Support

Strong Evidence:	Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay
Weak Evidence:

Reference

[1] PubMed ID:	30478856
Disease Name:	Thyroid Cancer, Papillary
Sample:	PTC tissues and cell lines
Dysfunction Pattern:	Interaction[sponging miR-613]
Validated Method:	qRT-PCR
Description:	Our findings revealed that the level of LINC00460 was significantly upregulated in PTC tissues and cell lines.These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR-613 in PTC.
Causality:	Yes
Causal Description:	Cellular experiments exhibited that knockdown of LINC00460 decreased proliferative, migratory, and invasive abilities of PTC cells.
Clinical-realted Application:	Our findings revealed that the level of LINC00460 was significantly upregulated in PTC tissues and cell lines, which was positively correlated with advanced tumor-node-metastasis (TNM) stage and lymph node metastasis.

[2] PubMed ID:	32021436
Disease Name:	Thyroid Cancer, Papillary
Sample:	PTC tissues and cells
Dysfunction Pattern:	interaction[miR-539]
Validated Method:	Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay
Description:	LINC00460 expression was markedly up-regulated in PTC tissues and cells compared to their corresponding controls by quantitative real-time PCR (qRT-PCR).These findings indicated that LINC00460 can modulate MMP-9 expression to promote cell proliferation, invasion and apoptosis through targeting miR-539, suggesting act as an oncogenic RNA in PTC and provide a new therapeutic perspective.
Causality:	Yes
Causal Description:	Meanwhile, LINC00460 knockdown notably inhibited the proliferation capacity, accelerated the apoptosis and down-regulated the invasion-related proteins (MMP-2, MMP-9, ZEB1) expression.
Clinical-realted Application:

[3] PubMed ID:	31870440
Disease Name:	Thyroid Cancer, Papillary
Sample:	PTC tissues and cells
Dysfunction Pattern:	Regulation[LINC00460/miR-485-5p/Raf1 axis]
Validated Method:	Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:	LINC00460 was upregulated in PTC tissues and cells. Raf1 was upregulated in PTC tissues, but miR-485-5p was down-regulated.Bioinformatics prediction revealed that LINC00460 had binding sites with miR-485-5p, which was validated by luciferase reporter assay. In addition, miR-485-5p was confirmed to directly target Raf1 3'-UTR. Moreover, LINC00460 promoted PTC progression by sponging miR-485-5p to elevate the expression of Raf1. Knockdown of LINC00460 restrained tumor growth in vivo.
Causality:	Yes
Causal Description:	LINC00460 knockdown suppressed proliferation, migration, invation and EMT of PTC cells.
Clinical-realted Application:	High LINC00460 expression was associated with poor prognosis.

LncRNADisease v3.0

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