Entry Detail

General Information

Database ID: LDA0001954
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00511
Full Name:long intergenic non-protein coding RNA 511
Category:LncRNA
Species:Homo sapiens
Synonyms:LCAL5|onco-lncRNA-12
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):72598041End Site(bp):72640472
External Links:
Ensembl ID:ENSG00000227036
Ensembl Transcript ID:N/A
Entrez Gene:400619.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:32   
More Information
Causal Disease Number:26
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Adenocarcinoma of Lung  (Score: 1)
Adenocarcinoma of Lung  (Score: 1)
Breast Neoplasms  (Score: 0.999998)
Breast Neoplasms  (Score: 0.999998)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3498
Disease Name:pancreatic ductal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:ductal adenocarcinoma of the pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:110
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
circMYOF  (Score: 0.731059)
circBFAR  (Score: 0.731059)
hsa_circ_000684  (Score: 0.731059)
circSLIT2  (Score: 0.731059)
hsa_circ_0005105  (Score: 0.731059)
circEYA3  (Score: 0.731059)
circNEIL3  (Score: 0.731059)
hsa_circ_0047744  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//FISH//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:28984028
Disease Name:pancreatic ductal adenocarcinoma
Sample:PDAC cell lines and patient specimens
Dysfunction Pattern:Interaction(miR-29b-3p/VEGFA)
Validated Method:qRT-PCR//Western Blot//FISH
Description:The aberrant up-regulation of linc00511 was detected in PDAC cell lines and patient specimens compared with controls. Mechanistically, linc00511 could up-regulate VEGFA via its competing endogenous RNA (ceRNA) activity on hsa-miR-29b-3p. In summary, our results define an important axis controlling proliferation, invasion and tumour angiogenesis in PDAC.
Causality:Yes
Causal Description:Functionally, linc00511 depletion in PDAC cells decreased proliferation, migration, invasion and endothelial tube formation.
Clinical-realted Application:An increase in linc00511 expression indicates the adverse clinical pathological characteristics and poor prognosis.