Entry Detail

General Information

Database ID: LDA0001959
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00511
Full Name:long intergenic non-protein coding RNA 511
Category:LncRNA
Species:Homo sapiens
Synonyms:LCAL5|onco-lncRNA-12
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):72598041End Site(bp):72640472
External Links:
Ensembl ID:ENSG00000227036
Ensembl Transcript ID:N/A
Entrez Gene:400619.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:32   
More Information
Causal Disease Number:26
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Adenocarcinoma of Lung  (Score: 1)
Adenocarcinoma of Lung  (Score: 1)
Breast Neoplasms  (Score: 0.999998)
Breast Neoplasms  (Score: 0.999998)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:32953492
Disease Name:lung squamous cell carcinoma
Sample:
Dysfunction Pattern:regulation[miR-150-5p,TADA1]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP//Western Blot
Description: LINC00511 was upregulated in LUSC tissues in TCGA database compared to adjacent non-tumor counterparts, and its expression level was strongly associated with tumor stage. our study highlights that LINC00511 facilitates LUSC progression via sequestering miR-150-5p and targeting TADA1, suggesting a need for development of a strategy for therapeutic targeting of LINC00511 in LUSC.
Causality:Yes
Causal Description:LINC00511 deficiency significantly suppressed LUSC cell proliferation and migration.
Clinical-realted Application: LINC00511 was upregulated in LUSC tissues in TCGA database compared to adjacent non-tumor counterparts, and its expression level was strongly associated with tumor stage.