Entry Detail

General Information

Database ID: LDA0001974
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00519
Full Name:long intergenic non-protein coding RNA 519
Category:LncRNA
Species:Homo sapiens
Synonyms:C14orf30|c14_5317
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):51304311End Site(bp):51328385
External Links:
Ensembl ID:ENSG00000258955
Ensembl Transcript ID:N/A
Entrez Gene:161342.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
lung squamous cell carcinoma  (Score: 0.731059)
lung squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//FISH//RIP//qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32297697
Disease Name:lung squamous cell carcinoma
Sample:LUSC tissues and cell lines
Dysfunction Pattern:regulation[miR-450b-5p/miR-515-5p/YAP1 axis]
Validated Method:RNA Pull-Down//qRT-PCR//RIP//FISH//Luciferase Report Assay
Description:Elevated level of LINC00519 was identified in LUSC tissues and cell lines. H3K27ac-activated LINC00519 acts as a competing endogenous RNA (ceRNA) to promote LUSC progression by targeting miR-450b-5p/miR-515-5p/YAP1 axis.
Causality:Yes
Causal Description: Then, loss-of-function assays suggested the inhibitive role of silenced LINC00519 in cell proliferation, migration, invasion and tumour growth and promoting effect on cell apoptosis in LUSC.
Clinical-realted Application:High LINC00519 level predicted unsatisfactory prognosis.