Entry Detail

General Information

Database ID: LDA0001975
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00518
Full Name:long intergenic non-protein coding RNA 518
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf218|LENOX
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):10427785End Site(bp):10434822
External Links:
Ensembl ID:ENSG00000183674
Ensembl Transcript ID:N/A
Entrez Gene:221718.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Melanoma  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30720156
Disease Name:Uterine Cervical Neoplasms
Sample:CC tissues
Dysfunction Pattern:Regulation[JAK/STAT3 signaling]
Validated Method:Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Colony Formation Assay//Transwell Assay
Description:We found that LINC00518 was upregulated in CC tissues and associated with International Federation of Gynaecology and Obstetrics (FIGO) stage, lymph node metastasis, depth of cervical invasion and poor survival of CC patients. The present work first suggests that LINC00518 acts as an oncogene in CC via regulation of the JAK/STAT3 signaling pathway.
Causality:Yes
Causal Description:Furthermore, knocking down LINC00518 expression significantly suppressed CC cell proliferation, migration and invasion, and induced apoptosis in vitro.
Clinical-realted Application:We found that LINC00518 was upregulated in CC tissues and associated with International Federation of Gynaecology and Obstetrics (FIGO) stage, lymph node metastasis, depth of cervical invasion and poor survival of CC patients.