Entry Detail

General Information

Database ID: LDA0001976
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00518
Full Name:long intergenic non-protein coding RNA 518
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf218|LENOX
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):10427785End Site(bp):10434822
External Links:
Ensembl ID:ENSG00000183674
Ensembl Transcript ID:N/A
Entrez Gene:221718.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Melanoma  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Colony Formation Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//IHC//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:33937054
Disease Name:Adenocarcinoma of Lung
Sample:LUAD specimens and cell lines
Dysfunction Pattern:Interaction(miR-185-3p/MECP2)
Validated Method:In Vivo Experiment//IHC//Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Description:We found that LINC00518 was highly expressed in LUAD specimens and the high-expression was negatively correlated with the overall survival rates. This finding was also proved in the LUAD cell lines. Through a series of in vitro and in vivo experiments, we proved that LICN00518 promoted the cell growth of LUAD by regulating the cell cycle. Moreover, LICN00518 upregulated the expression of MECP2 by mutagenesis of miR-185-3p.
Causality:Yes
Causal Description:Through a series of in vitro and in vivo experiments, we proved that LICN00518 promoted the cell growth of LUAD by regulating the cell cycle.
Clinical-realted Application:We found that LINC00518 was highly expressed in LUAD specimens and the high-expression was negatively correlated with the overall survival rates.