Entry Detail

General Information

Database ID: LDA0001977
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00518
Full Name:long intergenic non-protein coding RNA 518
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf218|LENOX
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):10427785End Site(bp):10434822
External Links:
Ensembl ID:ENSG00000183674
Ensembl Transcript ID:N/A
Entrez Gene:221718.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Melanoma  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1909D008545
Disease Name:melanomaMelanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Alias:Naevocarcinoma//malignant melanomaMelanoma//Melanomas//Malignant Melanoma//Malignant Melanomas//Melanoma, Malignant//Melanomas, Malignant

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MALAT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TINCR  (Score: 0.985791)
LINC-PINT  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35813236
Disease Name:Melanoma
Sample:melanoma tissues and cells
Dysfunction Pattern:Interaction(EIF4A3/MITF axis)
Validated Method:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Description: In our study, LINC00518 was revealed to be upregulated in melanoma tissues and cells, and melanoma patients in high LINC00518 expression group had poorer prognosis as depicted in GEPIA database. Additionally, results of mechanism assays uncovered EIF4A3 could bind with LINC00518 and MITF, and LINC00518 recruited EIF4A3 to stabilize MITF mRNA. Finally, it was demonstrated that upregulation of MITF could partially abrogate the inhibitory impact of LINC00518 knockdown on melanoma cell malignant behaviors.
Causality:Yes
Causal Description:Functional assays revealed that LINC00518 depletion inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT).
Clinical-realted Application: In our study, LINC00518 was revealed to be upregulated in melanoma tissues and cells, and melanoma patients in high LINC00518 expression group had poorer prognosis as depicted in GEPIA database.

[2] PubMed ID:35189053
Disease Name:Melanoma
Sample:CMM tissues and cells
Dysfunction Pattern:Interaction(miR-526b-3p/EIF5A2 axis)
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Description:LINC00518 and EIF5A2 were up-regulated and miR-526b-3p was down-regulated in CMM tissues and cells. LINC00518 bound to miR-526b-3p and miR-526b-3p targeted EIF5A2. LINC00518 negatively regulated miR-526b-3p expression but positively regulated EIF5A2. Furthermore, EIF5A2 expression was negatively associated with miR-526b-3p expression.
Causality:Yes
Causal Description:Transfection of si-LINC00518, miR-526b-5p mimic or si-EIF5A2 weakened the proliferative, migratory, and invasive abilities of melanoma cells, while transfection of miR-526b-5p inhibitor or pcDNA-LINC00518 enhanced the progression of melanoma cells. Moreover, the proliferative, migratory, and invasive potentials of melanoma cells were decreased after co-transfection of si-EIF5A2 and pcDNA-LINC00518 compared with cells transfected with pcDNA-LINC00518 alone.
Clinical-realted Application:CMM patients with highly expressed LINC00518 showed decreased survival time than those with lowly expressed LINC00518.