Entry Detail

General Information

Database ID: LDA0001984
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00472
Full Name:long intergenic non-protein coding RNA 472
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf155|P53RRA
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):71407864End Site(bp):71420745
External Links:
Ensembl ID:ENSG00000233237
Ensembl Transcript ID:N/A
Entrez Gene:79940.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Acute Hepatic Injury  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3347D012516
Disease Name:osteosarcomaOsteosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Alias:Osteogenic sarcoma//Skeletal sarcoma//bone tissue neoplasm//osteoid sarcomaOsteosarcoma//Osteosarcomas//Osteosarcoma Tumor//Osteosarcoma Tumors//Tumor, Osteosarcoma//Tumors, Osteosarcoma//Sarcoma, Osteogenic//Osteogenic Sarcomas//Sarcomas, Osteogenic//Osteogenic Sarcoma

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:600
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
PVT1  (Score: 1)
GAS5  (Score: 1)
SNHG16  (Score: 1)
LINC00662  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00662  (Score: 1)
ZFAS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32256209
Disease Name:Osteosarcoma
Sample:OS tissues and cell lines
Dysfunction Pattern:interaction[miR-300 and FOXO1]
Validated Method:qRT-PCR
Description:The expressions of LINC00472 were inhibited in OS tissues and cells, and were negatively related to the expressions of miR-300. From all the experiments and observations, we demonstrated that LINC00472 could be a potential tumor suppressor in OS through interacting with miR-300 and FOXO1.
Causality:Yes
Causal Description:LINC00472 over-expressions decreased cell proliferation abilities and colony formation abilities.
Clinical-realted Application: