Entry Detail

General Information

Database ID: LDA0002002
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00485
Full Name:long intergenic non-protein coding RNA 485
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):102809283End Site(bp):102824399
External Links:
Ensembl ID:ENSG00000258169
Ensembl Transcript ID:N/A
Entrez Gene:283432.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Lung Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1324D008175
Disease Name:lung cancerLung Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A respiratory system cancer that is located_in the lung.Tumors or cancer of the LUNG.
Alias:Lung Neoplasms//Pulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:344   
More Information
Causal ncRNA Number:282
Network:
Top Causal ncRNAs:
OIP5-AS1  (Score: 0.999893)
OIP5-AS1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
circHIPK3  (Score: 0.985791)
GAS5  (Score: 0.985791)
PCAT1  (Score: 0.985791)
NNT-AS1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33237626
Disease Name:Lung Neoplasms
Sample:lung cancer tissue
Dysfunction Pattern:regulation[miR-298/c-Myc axis]
Validated Method:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:In this study, we found that the expression of Linc00485 was significantly increased in human lung cancer tissue and associated with malignant phenotypes, including tumour-node-metastasis (TNM) stage, metastasis and relapse. Overall, these findings indicate that Linc00485 overexpression down-regulates miR-298, resulting in the up-regulation of c-Myc and thereby promoting the development of lung cancer.
Causality:Yes
Causal Description: Furthermore, the proliferative, migratory and invasive abilities of lung cancer cells in vitro were significantly enhanced by overexpression of Linc00485 but inhibited by its silencing.
Clinical-realted Application:In this study, we found that the expression of Linc00485 was significantly increased in human lung cancer tissue and associated with malignant phenotypes, including tumour-node-metastasis (TNM) stage, metastasis and relapse.