Entry Detail

General Information

Database ID: LDA0002004
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00477
Full Name:long intergenic non-protein coding RNA 477
Category:LncRNA
Species:Homo sapiens
Synonyms:C12orf67|FAM191B
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):24566964End Site(bp):24584168
External Links:
Ensembl ID:ENSG00000197503
Ensembl Transcript ID:N/A
Entrez Gene:144360.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Polycystic Ovary Syndrome  (Score: 0.731059)
Polycystic Ovary Syndrome  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11612D011085
Disease Name:polycystic ovary syndromePolycystic Ovary Syndrome
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Alias:Multicystic ovaries//PCOS//Polycystic Ovarian disease//Polycystic ovaries//Stein-Leventhal synd.//Stein-Leventhal syndrome//polycystic ovaryPolycystic Ovary Syndrome//Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:126   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
hsa_circ_0043532  (Score: 0.985791)
hsa_circ_0043532  (Score: 0.985791)
MALAT1  (Score: 0.731059)
BANCR  (Score: 0.731059)
LINC00477  (Score: 0.731059)
lncROR  (Score: 0.731059)
H19  (Score: 0.731059)
lnc-CCNL1-3:1  (Score: 0.731059)
GAS5  (Score: 0.731059)
lnc-MAP3K13-7:1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:ISH//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33622342
Disease Name:Polycystic Ovary Syndrome
Sample:serum of PCOS patients
Dysfunction Pattern:Interaction(miR-128 axis)
Validated Method:ISH//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay
Description:LINC00477 was significantly upregulated in the serum of PCOS patients as well as PCOS mouse models. Moreover, miR-128 mimics partially abrogated the effect of LINC00477 on granulosa cells.
Causality:Yes
Causal Description:LINC00477 overexpression inhibited the proliferation and promoted the apoptosis of granulosa cells, whereas knockdown of LINC00477 yielded the opposite effects.
Clinical-realted Application: