Entry Detail

General Information

Database ID: LDA0002010
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00473
Full Name:long intergenic non-protein coding RNA 473
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf176|LNC473|bA142J11.1
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):165924048End Site(bp):165988039
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:90632.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Molecular Epidemiology  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//CCK8//RIP//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31894297
Disease Name:Glioma
Sample:glioma tissues,cell lines
Dysfunction Pattern:Regulation[YAP1‑TEAD1‑Hippo signaling]
Validated Method:Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:In the present study, LINC00473 was significantly increased in glioma tissues and in cell models, and predicted a poor prognosis in patients with glioma. Mechanistically, LINC00473 functioned as a competing endogenous (ce)RNA to decrease microRNA (miR)‑195‑5p expression. Moreover, Yes‑associated protein 1 (YAP1) and TEA domain family member 1 (TEAD1) were identified as downstream targets of miR‑195‑5p, whose expression levels were inhibited by miR‑195‑5p. LINC00473 knockdown suppressed glioma progression through the decrease of miR‑195‑5p and subsequent increase of YAP1 and TEAD1 expression levels.
Causality:Yes
Causal Description:Notably, LINC00473 knockdown not only suppressed cell proliferation, invasion and migration of glioma cells, but also blocked cell cycle progression and induced apoptosis. Subcutaneous xenotransplanted tumor model experiments revealed that reduced LINC00473 expression was able to suppress in vivo glioma growth.
Clinical-realted Application:

[2] PubMed ID:31561732
Disease Name:Glioma
Sample:glioma tissues and cell lines
Dysfunction Pattern:Regulation[miR-637/CDK6 axis]
Validated Method:Western Blot//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:In the present study, LINC00473 was notably elevated in glioma tissues and cell lines. Thus, we demonstrated that LINC00473 could act as a ceRNA of miR-637 to promote glioma progression through regulating CDK6 expression, which provided a potential therapeutic target for treatment of glioma patients.
Causality:Yes
Causal Description:Loss function assays showed that LINC00473 knockdown decreased glioma cell proliferation, invasion and epithelial-mesenchymal transition (EMT) processes in vitro, and reduced tumor growth in vivo.
Clinical-realted Application:High LINC00473 expression was associated with advanced WHO grade (III-IV), low Karnofsky performance score (KPS), and poor prognosis.